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Current Edition

March 2015

Volume 1, Issue 1


Luteal Phase Progesterone and Four Decades Of In Vitro Fertilization: Many Questions Still Unanswered
Micah J Hill*

The rise of progesterone in natural human reproduction is exquisitely timed to embryo development. The luteinizing hormone surge induces oocyte maturation, ovulation, and progesterone production from the corpus luteum. Progesterone hormone action produces endometrial changes in gene expression, protein production, histologic appearance, and structural arrangements which all lead to an  endometrium receptive for implantation five to six days after ovulation. 

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Premature Progesterone Rise During in Vitro Fertilization: When to Freeze Embryos and When to Proceed with Embryo Transfer?
Micah J Hill
* and George Patounakis

In the natural menstrual cycle, progesterone does not begin to significantly rise until after the LH surge and is therefore precisely timed with ovulation. This leads to synchrony of embryo and endometrial development to facilitate successful embryo implantation. During the ovarian stimulation in in vitro fertilization (IVF) cycles, serum progesterone can be prematurely elevated as a result of the intermediate substrates in the estradiol steroid pathway.  

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A New Window of Opportunity for Improved Diagnosis of Diabetic Polyneuropathy
Dan Ziegler* and Nikolaos Papanas

Diagnosis of diabetic polyneuropathy (DPN), by far the commonest manifestation of diabetes mellitus (DM) in the nervous system, rests on careful clinical examination to reveal length-dependent, symmetrical, primarily sensory deficits in the distal parts of the lower extremities.   

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Lifestyle Modification Program, KOHNODAI Program
Hidekatsu Yanai*, Hisayuki Katsuyama, Akiko Kawaguchi, Sumie Moriyama, Hidetaka Hamasaki, Hiroshi Ohkubo, Keiko Osako, and Airi Sanada

Obesity is known to be associated with metabolic disorders, such as glucose intolerance, hypertension and dyslipidemia. Especially, metabolic abnormalities in obesity have been shown to be frequently associated with abdominal obesity.    

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Nutritional Therapy and Glycemic Variability among People with Diabetes
Refaat A Hegazi*, Rachel A Johnson, Amy A Devitt

Glycemic variability (GV) represents the acute fluctuation of blood glucose levels from peak to nadir. Over the last decade, GV has increasingly become part of the dialogue surrounding glycemic control, as evidenced by the growingnumber of articles published on this topic over the past few years.     

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Case Report

Development of Thyroid-Stimulating Antibodies and Thyrotoxicosis in a Case of Advanced Follicular Thyroid Carcinoma
Shoko Natsuda, Ichiro Horie, Takao Ando*, Atsushi Kawakami

It is extremely rare that thyroid cancer produces enough thyroid hormone to cause thyrotoxicosis. We report the case of a 69-year-old Japanese female who developed thyrotoxicosis associated with advanced follicular thyroid carcinoma. The patient had been under levothyroxine replacement therapy for 10 years after a total thyroidectomy, and had undergone radioiodine therapy three times because of multiple lung and bone metastases.

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