Jacobs Journal of Experimental Dermatology
Articles in Press
Volume 1 Issue 4
Forehead Augmentation with Hyaluronic Acid
Mohannad A Alsufyani*, Maram Alzain, M. D.,Mohammed Alsufyani, M. D
An integral part of the face, the forehead region constitutes the upper one-third of the countenance. When soft tissue resorption occurs, the beautiful bossing shape of the forehead that conveys the beauty of a female is lost. As the exaggeration of the supraorbital bones becomes more apparent, more masculine features are reflected. Various methods have been used for the augmentation of the forehead, including autologous fat grafts, alloplastic materials and methylacrylate. Hyaluronic acids are most commonly used material for soft tissue augmentation. We demonstrate herein the effectiveness and safety of restoring the soft tissue deflation of the forehead region when seeking to retain the beautiful convex female shape by using hyaluronic acid.
Successful Treatment with Adalimumab in a Patient with Psoriasis vulgaris after Infliximab-Related Liver Injury
Chika Ohata*, Bungo Ohyama, Hiroshi Nagata, Hiroshi Saruta, Minao Furumura, Takekuni Nakama
Liver injury caused by infliximab is rare. Only 2 cases have been reported, and both of them were successfully treated with etanercept after cessation of infliximab. No recurrence of liver injury during the treatment of etanercept was considered to be due to no cross reactivity with infliximab. We present a 36-year-old male with psoriasis developing liver injury with infliximab. Adalimumab has been suspected to recur liver injury because of similar mechanism of action to that of infliximab. However, our case was successfully treated with adalimumab without liver-function abnormalities. Adalimumab is a useful substitute for infliximab, suggesting toxicity or antigenicity of mouse/human chimera monoclonal antibody against TNF-α.
Opinions of Japanese patients with Psoriasis regarding treatment with Biological Agents
Chika Ohata*, Bungo Ohyama, Fumitake Ono, Tadashi Karashima, Takahiro Hamada, Norito Ishii, Yohei Natsuaki, Hiroshi Saruta, Michi Gohara, Naomi Tani, Minao Furumura, Takekuni Nakama
In our recent study, we revealed that the drug survival rate of adalimumab is shorter in Japanese patients than that in European patients, raising the hypothesis that a low self-injection rate, which results in frequent hospital visits, may be related to the shorter drug survival rate. This prompted us to assess opinions among patients with psoriasis regarding biological agents and self-injection. Questionnaires were completed by 79 patients who visited the Department of Dermatology of Kurume University School of Medicine between January and April 2014.
Contribution of Silver Sulfadiazine in Chronic Leg Ulcers Healing In Côte Ivoire
Kassi K*, Djeha D, Kouame K, Kouassi A, Ahogo C, Kaloga M, Ecra E
Chronic wounds are defined as wounds, which have failed to proceed through an orderly and timely reparative process to produce anatomic and functional integrity over a period of 3 months. This cicatrization process goes through 3 phases, as follow, inflammatory phase, proliferation phase, and maturation phase. Meanwhile, this maturation could be delay by several factors such as infections and co-morbidities (diabetes, venous insufficiency, under nutrition; etc…). In developed countries, chronic leg ulcer represents a major cause of morbidity and bad quality of life which impacts negatively public health budget.
Epidermodysplasia Verruciformis Associated with Scleroderma
Bilal Bulut, MD, Belma Türsen, MD, Prof. Dr. Tamer İrfan Kaya, MD, Prof.Dr. Ümit Türsen*, MD, Rabia Bozdogan Arpaci,MD
Epidermodysplasia verruciformis (EV) is a rare genodermatosis characterized by flat warts or scaling macules resembling pityriasis versicolor. We describe a 30-year-old man with EV associated with scleroderma. The lesions, persisting for more than 10 years, consisted of widespread planar warts on the backs of the hands and wrists, and reddish-brown macules on the trunk, neck and face. He also presented with sclerodermatous skin changes on the lower extremities last 2 years. There are 2 case reports about autoimmune diseases including vitiligo and autoimmune polyendocrinopathy associated with EV in the literature.
Oral Tranexamic Acid Versus Triple Combination for The Treatment of Melasma
Melasma is an irregular brown or grayish-brown facial hypermelanosis, often affecting women, especially those living in areas of intense ultraviolet radiation. The precise cause of melasma remains unknown; however, there are many possible contributing factors. The common contributing factors include genetic predisposition, pregnancy, use of oral contraceptives, endocrine dysfunction or hormone treatments and exposure to UV light.
Skin Surface pH and Topical Emollient: Fact or Artifact?
Miranda A. Farage*, William Hood, Mauricio Odio, Enzo Berardesca and Howard Maibach
The body skin pH can usually vary from 4.0 to 7.0 depending on location. The presence of natural acidic compounds on the skin surface helps maintain the skin’s physicochemical properties as well as its protective functions. Since the slightly acidic pH of the skin is extremely important for the skin’s protective function, the skin is widely known as “acid mantle.” Factors such as age, race, gender, body sites, biochemical differences, and even washing affect the pH of the stratum corneum.
The First Report of Septic Arthritis of the Pubic Symphysis Associated With Fournier’s Gangrene
Osamu Okamoto*, Seiichi Sato, Kaho Matsuda, Noriko Gamachi, Ken-ichi Hirai, and Hiroyuki Hashimoto
A 66-year-old male was diagnosed as Fournier’s gangrene with 6% skin involvement. The patient underwent debridement followed by the placement of a skin graft. After the completion of the treatment, a small granulomatous ulcer with an abscess remained in the pubic area. A wide excision of the abscess was performed, revealing the presence of necrotic tissue in the pubic symphysis; however, no evidence of osteomyeliitis was observed. The excised tissue revealed necrotic cartilage, and enterococcus was detected.
Allergic Contact Dermatitis to p-phenylenediamine and Some of its Reaction Products
E. Young*, E. Zimerson, C. Svedman, M. Bruze
Contact allergy to hair dyes is prevalent among hairdressers and their consumers. The potent sensitizer p-phenylenediamine (PPD) is a common colour substance in oxidizing permanent hair dyes. The complex hair dye cocktail consists of many ingredients. When the hair dye is used oxidative agents are added and PPD can be transformed into new substances. The substances, being formed and applied to the hair, when PPD is used in hair dyes, are partly unknown.