Jacobs Journal of Nanomedicine and Nanotechnology
Volume 1 Issue 1
Biological Effects of Functionalized Multi-Walled Carbon Nanotubes on Human Cancer and Normal Cell Lines
Stefano Bellucci*, Federico Micciulla, Silvia Bistarelli, Simona Dinicola, Pierpaolo Coluccia, Alessandra Cucina ,Mariano Bizzarri, Angela Catizone, Giulia Ricci
Multi-walled carbon nanotubes (MWCNTs) have a great biomedical potential, even though their toxicology in vitro remain still controversial. Since it is well known that nanotube aggregates are more toxic than monodispersed nanotubes, the aim of our study was, firstly, to provide a new method that makes the nanotubes themselves monodispersed.
Challenges in the Medicinal Applications of Carbon Nanotubes (CNTs): Toxicity of the Central Nervous System and Safety Issues
Ashok K Singh*
Carbon nanotubes (CNTs) are gradually emerging as a new option for possible use in neural prosthesis, drug delivery, cancer treatment, bioengineering, gene therapy and regeneration therapy. With an increase in the development and application of CNT-based medicinal products, the potential hazards of CNTs to biological systems are getting greater public attention.
Establishment of a Highly Specific Enzyme Immunoassay for Digoxin in Human Serum
Yasuhiko Higashi*, Yukari Ikeda, Norihiko Yamamoto, and Youichi Fujii
We previously developed a radioimmunoassay for digoxin using an antiserum raised against digoxin 3’-hemisuccinate -bovine serum albumin. In the present study, we aimed to establish an enzyme immunoassay (EIA) for measuring serum digoxin level in patients, using digoxin 3’-hemisuccinate-β-D-galactosidase as an enzyme-labeled antigen. The developed enzyme immunoassay showed a quantification range of 0.2 to 10 ng/ml and exhibited high specificity for digoxin, with low levels of cross-reaction to dihydrodigoxin (12.3%), digitoxin (7.84%), digoxigenin bisdigitoxoside (0.31%), digoxigenin monodigitoxoside (0.19%), and digoxigenin (0.05%).
Fire-Retardant Performance of Intumescent Coatings Using Halloysites as a novel Fire-Retardant Additive
Javier Sacristan Bermejo*, Leandro Gonzalez Rovira, Rodriguez-Fernández
This paper aims to synthesize and characterize an effective intumescent fire protective coating that incorporates halloysite as fire-retardant additive. The effect of the fire-retardant additives and their concentration on the fire protection performance of epoxy-carbon fibre composites were studied using cone calorimetry according to ISO-5660-1. Different modes of degradation, depending on the type and concentration of the additives were identified by analyzing the SEM images and cone calorimetry results. The fire behavior produced by the intumescent paints has demonstrated improvement of epoxy-carbon fibre composites thermal stability and fire performance.
Detection of the Immune Response during in vivo mapping of the Lymphatic system: A profile of 99mTc-Antimony Trisulfide Colloid and other Radioactive-Nanoparticles
Since the 1970’s, nuclear medicine clinics around the world have employed radioactive-nanoparticles for many different diagnostic studies in man. Currently the most important application of γ-emitting nanoparticles is to map the lymphatic system in cancer patients, and the β-emitting particulate agents are for treating arthritic joints. This review summarizes the current developments in diagnostic lymphoscintigraphy that employ radioactive nanoparticles, with a special emphasis on 99mTc-antimony trisulfide colloid, and it also describes the key cellular and molecular events in vivo during an immune response.