Jacobs Journal of Neurology and Neuroscience
Articles in Press
Volume 2 Issue 3
Frontal Executive Functions in Medication Overuse Headache
Hüseyin Alparslan Sahin, Yakup Türkel, Esen Ozgan Sahin, Taner Özbenli
Migraine is the second most common cause of the primary headache after tension-type headache. It is characterized by generally unilateral attacks lasting 4-72 hours, presenting as throbbing headaches. It is unclear whether the cognitive impairment is a clinical feature of migraine. Many migraine patients report subjective cognitive impairments such as forgetfulness, inattentiveness and psychomotor tiredness.
Primary Lateral Sclerosis/Stiff Person Syndrome with a Response to Intravenous Immunoglobulin
Michael T Flannery*, Deborah Humphrey
Primary Lateral Sclerosis is a sister disease of ALS whose differences focus on the predominance of upper motor neuron findings with very little to no lower motor neuron findings. Our patient presented initially with spasticity predominately of the lower extremities with UMN findings of hyperreflexia in the patellar reflexes and an abnormal Babinski on the left. Eventually, the patient developed intermittent proximal spasms and increased spinal stiffness leading to decreased range of motion and mobility. At this time, the patient also had the presence of anti-Glutamic acid decarboxylase (GAD) antibodies which can be seen in 60% of patients with Stiff Person Syndrome.
The Case of a Metastatic Ductal Cell Carcinoma Followed by Mitoxantrone Use a Case Report
Masoud Ghiasian*, Sahar Moradee, Amir Zebarjadian
Multiple Sclerosis is a chronic inflammatory demyelinating disease of the CNS of an unknown cause. The course is extremely variable. After a number of years, there is an increasing tendency for patients to enter the phase of Slow Steadiness or Fluctuating Deterioration of neurologic function (Secondary Progressive). Secondary Progressive MS is more difficult to treat than relapsing and remitting form of the disease. At this step, one of the treatments is Mitoxantrone.
Orexin Receptor Gene Polymorphisms in Japanese Migraine Patients with Medication Overuse Headache
Masakazu Ishii*, Masaaki Ishibashi, Hirotaka Katoh
Patients with migraine disease are known to be complicated with medication overuse headache. Although it has been shown that orexin-1 receptor (HCRTR1, rs2271933) and orexin-2 receptor (HCRTR2, rs2653349) gene polymorphisms are contributed the pathophysiology of migraine, the relationship between these polymorphisms and medication overuse headache (MOH) is unknown. Therefore, we hypothesized that HCRTR1 and HCRTR2 gene polymorphisms may modify the aggravation of migraines due to medication overuse.
A Novel Sign for Cerebellar Lesions Detection Based on Cognitive Functions
de Font-Réaulx Enrique MD*, Díaz-Victoria Ana Ruth, Ramos Cuevas María del Rosario, Cantú Brito Carlos MD, PhD
The cerebellum has been related almost exclusively to motor functions, in spite of the growing evidence that relates the cerebellum to cognitive functions. We describe a clinical maneuver and sign designed to detect cerebellar lesions, based on cognitive function evaluation. To determine the usefulness of the proposed maneuver to detect or exclude cerebellar lesions as a diagnostic test.
NF1 Clinical Elements and The NF1 Neurofibroma Burden
Vincent M. Riccardi*
In order to understand the elements of the NF1 syndrome, we must recognize the three distinct types of these elements, namely, features, consequences and complications. These distinctions become even more cogent and compelling when we consider the NF1 neurofibroma burden and potential treatment strategies to minimize that burden.
Regularity of cognitive variation after stroke and its related factors
Jin Wang, Qing-yu Fan, Hong Zhang,Peng Liu, Hua Su, Jin Qiao, Rui Li, Qiu-min Qu*
Stroke is a major cause of disability and mortality worldwide mainly affecting mid-aged and elder populations.Besides physical disorders, stroke also impairs cognitive function. Cognitive impairment influences patients’ daily life as well as the recovery of physical function. It is believed that cognitive impairment is a major reason for the disability after stroke. Therefore, the prevention and treatment of poststroke cognitive impairment (PSCI) is important for the improvement of stroke recovery and the quality of patients’ life. Previous studies have revealed that the prevalence of PSCI ranges from 35% to 47% after three months of stroke.
Impairment of Memory Function as a Marker of Progression from Behçet’s Disease to Neuro- Behçet’s Disease
Hiroaki Oguro*, Hiroyuki Takayoshi, Satoshi Abe, Shuhei Yamaguchi
Behçet’s disease (BD) is a multisystem relapsing inflammatory disorder characterized by recurrent oral and genital ulceration, skin lesions, arthritis and uveitis. The appearance of central nervous system (CNS) involvement in BD, usually called neuro- Behçet’s disease (NBD), is the majority of patients present acute meningoencephalitis with focal lesions on MRI, followed by slowly progressive dementia with progressive brain stem atrophy. Cognitive impairment is evident in 46% of BD patients, with memory being the most severely affected cognitive domain.