NIH Article Edition
Immune response to immunodominant Mycobacterium tuberculosis antigen ESAT6- derived peptide is HLA-haplotype dependent
Michele Smart, Marshall Behrens, Luckey David, Catherine Conway, Veena Taneja*
The antigenic proteins of Mycobacterium tuberculosis (Mtb) have been defined. We used synthetic peptides of secreted antigens, early secreted antigenic target 6 (ESAT-6) and cultural filtrate protein-10 (CFP-10), of Mtb and characterized the immune response in context of HLA genes. Humanized mice lacking endogenous class II molecules but expressing various human DR and DQ HLA transgenes singly or as a haplotype were used to study the HLA-mediated immune response to peptides.