Jacobs Journal of Bone Marrow and Stem Cell Research (ISSN 2381-2745)




Dr. Manuel Abecasis
Technical University of Lisbon, Portugal


  • Biology of Blood
  • Marrow and Transplantation
  • Stem Cell Therapy
  • Leukaemia Research
  • Stem Cell Transplant system
  • Haematopoiesis
  • Study of Lymphatic system
  • Spinal cord injury repair
  • Stroke and traumatic brain injury repair
  • Stem Cell bank
  • Experimentation and applications
    of Plant and animals stem cells
  • Stem cell controversy
  • Stem cell markers

Open access truly expands shared knowledge across scientific fields; it is the best path for accelerating multi-disciplinary breakthroughs in research.

What is Open Access?

By Open Access, we mean the free, immediate, availability on the public Internet of those works which scholars give to the world without expectation of payment, permitting any user to read, download, copy, distribute, print, search or link to the full text of these articles.

Why Open Access?

Funders invest in research in order to accelerate the pace of scientific discovery, encourage innovation, enrich education, and stimulate the economy to improve the public good. They recognize that broad access to the results of research is an essential component of the research process itself. Research advances only through sharing of results, and the value of an investment in research is only maximized through wide use of its results.

Yet, too often, research results are not available to the broadest community of potential users. The Jacobs Publisher Open access journals provide a new opportunity to bring information to a wider audience at virtually no marginal cost, and allow them to use it in new, innovative ways. This has resulted in a call for new framework to allow research results to be more easily accessed and used.

Open access publishing promotes knowledge transfer by mouse click to global scientific community; users can discuss the articles in their research communities.
Open access publishing covers various initiatives and projects across the globe to make academic studies and results available to a wider readership.
In an Open Access publishing model the author retains the copyright, manuscripts are published relatively quickly, they are peer-reviewed by experts and quality will be maintained.
As open access publications has given unrestricted access, free of charge to world, even people in poorer countries who usually lack the financial means can access and use them.
Open access includes the increased visibility and citability of publications and all the other advantages of digital use, such as availability anytime, anywhere, being easier to find using search engines and the option of saving, copying and printing an article by user.
In a one word Open access is a driving force to bring research work online to global scientific world.

Editor Guidelines

We recognize the importance of our Editor/ Editor-in-Chief who play crucial role in Open Access Publication right from forming of editorial board to publishing of manuscripts in fostering the quality of a publication and the journals content. Editor/ Editor-in-Chief render invaluable services to Open Access through their eminence in research & expertise in respective field.

Responsibilities and Guidelines of the Editors

Editors are requested to assign the articles to the reviewers received from the editorial office. Articles are assigned based on the research interest of the editors. If the editors are busy with the other commitments, they can directly inform to the editorial office which enables us to assign the same article to other editors having similar research interest.
Timely contribution of the articles/ editorials/ short communications for upholding the issues constantly in the journal.
Encouraging the submission of the quality articles by recruiting authors or referring colleagues.
To determine the quality of the article once it is received from the editorial office.
Timely response to the editorial office to complete the review process within the provided timeline.
There is no limit for the editors to process the articles. It depends on the editors’ interest & his involvement in other commitments.
We encourage editors to provide new ideas/ suggestions for the development of the journal.
Editor has to monitor the complete peer review process to maintain the standards of the journal.
Editors need to ensure the protection of individual data and maintain confidentiality. While considering case reports and patient photographs, it is always suggested to obtain informed consent in written format.
Editors should ensure that all the articles are published with respect to the scope of the journal based on relevancy, integrity, scientific strength, new inputs, potential interest, completeness, clarity and ethics. Also assure that decisions given upon manuscripts are not affected by the authors’ origin, personal issues, nationality, ethnicity, race, religion or political beliefs. Decisions must be provided strictly based on the articles scientific validity and importance to the scientific community.


Review Process
Selection of reviewers
Reviewers Instructions
1. Review Process:

Reviewers play a major role in judging the quality of submitted manuscripts, articles or journals along with the Editorial Board Members through Peer-Review process. EB members help in handling the submitted manuscripts based on their expertise. They can accomplish the peer review process based on their own knowledge and experience or they can assign this task to the reviewers. The assigned reviewers are supposed to submit their comments to Editorial office by inclining to one of the below decision, the final decision maker is the assigned EB member. The identity of the reviewers is confidential to the authors at any time either during the process of review or after its publication. The papers should not be assigned to other people without Editors permission.
Reviewers comments should support one of the below mentioned acts.

• Accept it unconditionally
• Accept it with Minor revision
• Major revision
• To reject it outright (explain reason in report)

2. Selection of Reviewers:

Selection of reviewers for a particular manuscript is the responsibility of Jacobs’s publishers. It is based on many factors like expertise, proficiency and excellence in their particular field and their knowledge of past performance.
As part of our editorial procedure, we grant potential reviewers before sending them manuscripts to review. These Reviewers should keep in mind that even these initial messages or conversations contain confidential information, should be regarded as such.

3. Reviewer instructions:

Anonymity: Though reviewers are anonymous throughout the process, the review should be transparent, unbiased and should not involve personal or professional conflicts in the decision making.

Confidentiality: The articles received for review should be treated as confidential documents and should not be disclosed with anyone except with the assigned Editorial board and his reviewers. Reviewers are requested not to use any information of the assigned data even after publication unless they have the written statements of the authors.

Timely Review: The review process that results in timely publication provides a valuable service both to authors and to the scientific world.

Timeline: 10 days for Research/Review/Case Reports
07 days for Short Reports

Acceptance/ Rejection: The final decision of whether to accept or reject an article depends on the editor. Reviewers should mention a proper, sensible and fair reason to reject an article with recommendations.
Jacobs’s publishers allow reviewers to be notified about the outcome of the paper.

Feedback: The feedback to the reviewers along with the reviewer’s comments of that article will be sent to the reviewer to identify and transform themselves. Editorial Board who offers an opinion not accordance with the reviewer of that article should not feel that their recommendation is not considered and appreciated as it is the job of the EB members to make a decision.

It is easy to Submit the Manuscript at Jacobspublishers.

Send us an Attachment to :  addictionandtherapy@jacobspublishers.international


All submissions to Jacobs Publishers are published under the Creative Commons Attribution License which allows anyone to copy, distribute or reuse the articles by properly citing the author and the original source.

The procedure of submitting your manuscript is easy and quick.

Regular Issue submission

The steps need to be followed to submit your manuscript in the Regular Issue are as follows

Prepare your manuscript by following the Author Guidelines
Prepare a cover letter by downloading for Regular Issue CLICK HERE
Fill the data in the cover letter.
Mail the full manuscript along with the cover letter at: submissions@jacobspublishers.com
You will receive an acknowledgement within 24-48hours.
Special Issue submission

The steps need to be followed to submit your manuscript in the Special Issue are as follows

Prepare your manuscript by following the Author Guidelines at http://www.jacobspublishers.com/index.php/author-guidelines-in-foremostlinks
It should be clearly mentioned in the cover letter along with the title, if it is submitted to the Special Issue.Ex: Special Issue: Development of critical care in AIDS patients.
Download the cover letter for Special Issue: CLICK HERE
Fill the data in the cover letter mentioning about the Special Issue title.
Mail the full manuscript along with the cover letter at: specialissues@jacobspublishers.com
You will receive an acknowledgement within 24-48hours.
Note: Manuscript should be submitted in word/PDF file. A confirmation mail from the editorial office will assure you that your manuscript has been received.

Ethics in Publication

Ethical Principles: Jacobs authors are expected to stick to the ethical standards and conduct that remain mandatory in scholarly publishing. During the submission, authors need to mention that their work has not been submitted elsewhere, instances (if any) & conflicts need to be stated and plagiarism must be strictly cross checked. For Animal/ Human models, ethical authorization copy needs to be submitted.

Breach of copyright/ Plagiarism: Plagiarism can be defined as making a replica of the published content. Jacobs Publishers strictly against the Plagiarism. We cross check every submission that is been submitted to any of its peer reviewed Journal. Any submission that has partially /completely plagiarized content will be rejected immediately after submission.

Attribution Practice: Citations need to be acknowledged for previously published content. It is obligatory when new ideas or results are produced. If the author fails to reproduce citation for any previous work, it will be considered as technical plagiarism and the paper might be rejected immediately.

Conflicts of Interest: Jacobs Publishers involves double blind peer review system to avoid conflicts for the submitted manuscript. The authors should hold responsibility in providing conflicts if any to avoid further conflicts.

Confidentiality Protection: Editors, Reviewers need to be very cautious while handling the research work of the authors. It is ethically not accepted to use/disseminate the unpublished work. Use of the unpublished work might consider for legal actions.

Human and Animal Rights: Clear statements of ethical clearance documents need to be provided if applicable. The work involving animal models and human volunteers need to submit the essential statements.

Consents/Instances: Author needs to state consents and instances if any to avoid further obligations. Clear statement with written signature must be presented by the author while submitting his/her work.

Civility & Misconduct Allegations: Editors, Reviewers, Authors & the Journal staff are expected to adhere to the basic professional courtesy. Any verbal abuse, debates and insult is highly offended by the Jacobs Publishers. The supposed misconducts are severely offended further.

Jacobs Membership

As an endeavor in this noble mission we Jacobs publishers have rolled out a new concept called “Membership with Jacobs publishers” in which we provide maximum benefits to support your research. We hope this initiative of Membership with Jacobs publishers will inspire the global scientific & research community to usher in a new spirit of research. Following are the categories of memberships offered by Jacobs membership.

Individual Membership

In Individual Membership the registered scientist/ individual can publish unlimited submissions/ research work/ scientific work (Research/ review/ case reports/ editorial articles) for the period of one year.

Departmental Membership

In Departmental Membership the registered department can publish unlimited submissions/ research work/ scientific work (Research/ review/ case reports/ editorial articles) from entire department i.e. from Professors, Associate Professors, Assistant Professors and students of that department in our journal.

University/ Institutional Membership

In University/ Institutional Membership, the registered University/ academic institute can publish unlimited submissions/ research work/ scientific work (Research/ review/ case reports/ editorial articles) to any of Jacobs Publishers Journals.

Society/ Association Membership

In Society/ Association Membership, the registered Society/ Association can publish unlimited submissions/ research work/ scientific work (Research/ review/ case reports/ editorial) to any of Jacobs Publishers Journals.

Membership Fees

Type  Annual
Individual 3000 USD
Department 5000 USD
University 10000 USD
Industries 15000 USD
For further information regarding membership mail us to info@jacobspublishers.com


Article reprints from Jacobs Publishers commit to promote your research work with its professional quality reprints service delivered directly to your door at an affordable value. It aims to display the potential of the article at interviews, conferences, distribution to colleagues, seminars and other promotional activities. Reprints are produced from the final PDF of the article.

As all articles are open access, readers are free to download and/or print copies from the website, according to the terms & conditions of the Jacobs Publishers License . Authors must agree to distribute such reprints without any alterations, additions, deletions, overprinting, highlighting, promotional messages, or promotional attachments.

Author Reprints :

Author reprints are solely for the author’s personal, noncommercial use. Author reprints are available in both B/W and colour format with the addition of a standard cover page. Each article reprint is available with cover pages of the journal itself in order to maximise the impact and highlight the prestige of the content.

The front cover of the Reprints consists of :

Publisher logo
Name/logo of the journal
Title of article, complete list of authors, and Article information
Commercial Reprints :

Commercial reprints are high quality with specially designed covers. The reprints are an exact replica of the published article. These reprints are available only in the colour format with the customized cover page.

The front cover of the Commercial Reprints consists of :

Publisher logo
Name/logo of the journal
Title of article, complete list of authors, and Article information
Citation information

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Author Guidelines

Publishing your research content in Jacobs Publishers.

To help you to easily publish your manuscript and to ensure that you are aware of all the procedures of publishing, you are requested to go through our guidelines and detailed illustrations.

Following illustrations will help you to understand the steps involved in publishing your manuscript in Jacobs Publishers.

Select a Journal

How to select the journals ?

The journal you wish to publish your article or manuscript should be on the similar subject line as that of your article. For example “Jacobs Publishers ” will accept articles on Cancer Science and Clinical Research.

Prepare your Manuscript

You need to follow few guidelines to ensure that your article is well written and well received by the scientific community and researchers.


Plagiarism (defined by the Latin word plagiaries meaning an abductor and plagiare meaning to steal) is defined by the White House Office of Science and Technology Policy on delinquency in research as the stealing of another person’s ideas, tables, content, processes, results or words without citing the appropriate credit to be considered as crime. . The locality of the content is irrelevant: when it comes to plagiarism, content from the internet is equally comparable to information from appearing in a book or journal.

Plagiarisms are of types namely Self, Blatant and Unintentional: You might have extracted quite some content from your own existing paper. Such a plagiarism is termed self. Blatant is a very transparent way of copying contents from a few papers and unintentional is you might not have noticed while phrasing or paraphrasing.

Jacobs Publishers does not encourage any form of plagiarism, thus we strongly recommend you to check your article content before you submit manuscript to any of our journals. Plagiarism can be checked through online plagiarism software tools (although they are not completely reliable) to minimize further complications.

Formatting Prerequisites

1. Cover Letter
Cover letter must include the list of authors, and title of the manuscript. Mention the name of Jacobs Publishers and choice of interest to which the submission is sent. Cover letter should briefly communicate upon your study to previously published work. It should declare that the work is not published elsewhere. The article type should be mentioned (Research/ Review/ Short Communication/ Editorial/ Case Report/ Perspectives). Lists any suggested reviewers if any. Also, include current telephone and fax numbers, as well as postal and e-mail address of corresponding author to maintain communication.
Sample Cover Letter can be downloaded here: Cover Letter

2. File Types
Authors may submit their manuscript files in either of the mentioned formats like Word (as .doc or .docx), PDF. All the figures must be in either of gif/ tiff/ jpeg formats. The figure should be of high resolution and the figure legend word limit is 300 words.
If your manuscript is or will be in .doc format and contains equations, you must be following the instructions below to make sure that your equations are editable when the file enters production. We recommend you to use Math Type to create the equation.

3. Manuscript Organization
The following order remains same for all the article types except Abstract, Keywords remain mandatory for Research and Review. Word limits for Research/ Review/ Cases/ remain 5000 words where as for Short Communications/ Perspectives/ Editorials remain 1500 words. References cited are excluded in the word limit.

Order of Manuscript

Materials and Methods (Research)
Subheadings (Review and rest of the article types)
Results and Discussion (Results for Research/ Discussion for rest of the article types)



Title: The word limit of the title should not exceed 15 words. Title should be a proper description and relevant to the work provided. Font has to be set to Times New Roman Bold, Title case.

Abstract: Abstract should describe the main objectives of the study. It should be able to list out all the work briefly. Significance and the results of the study need to be precised briefly. Abstract ‘word limit’ should be limited to 300 words.
Note: Abstracts should be free of citations

Keywords: The major keywords used in the study need to be mentioned. Keywords limit is not more than 7-10 words

Abbreviations: If any abbreviations are used in the study, their first usage has to be mentioned in full form along with the usage abbreviation in brackets. If there are too many abbreviations they have to be mentioned below the keywords

Introduction: Introduction should be able to provide the background of the study. It should also provide comprehensive insight on the purpose of the study and its significance. Introduction needs to be descriptive and citations need to be provided

Materials and Methods: Particular details and/or practices for new approaches have to be mentioned. For the used protocols the proper citations has to be mentioned. Results have to be unique and not copied from any other sources. This section should present enough detail to permit researchers to fully replicate your study. We recommend authors to put forward detailed protocols for less well-established methods

Results and Discussions: This section might be further divided in subdivisions. Results and discussions must be providing the results. Illustrate the results of the experiments, the interpretation of these results, and the conclusions

Conclusion: Authors should elucidate how the results communicate to the theory presented as the basis of the study and provide a concise explanation of the allegation of the findings

Acknowledgements: Authors need to provide the funding details and the grant numbers if any. They might acknowledge their supported work

References: Jacobs Publishers use Vancouver referencing style. Authors should provide at least one online link in the references as following (preferably PubMed). Correct formatting of the references is important. Please use the following method for the reference list.

Reference Format: Author(s) Last name. Article title. Journal Name (Journal Short Name as in PubMed) Published year; Volume number: Page numbers.

Name of the author. Title of the book. Name of the chapter. Volume no. Edition. Edited by XXXX. Name of the city: Place; Year: Page numbers.


1.  Book Chapters:
Schnepf E: From prey via endosymbiont to plastids: comparative studies in dinoflagellates. In Origins of Plastids. Volume 2. 2nd edition. Edited by Lewin RA. New York: Chapman and Hall; 1993:53-76.

2. Complete Book:
Margulis L: Origin of Eukaryotic Cells. New Haven: Yale University Press; 1970.

Name of the author (Edition): Name of the conference: Date From –To Month Year; City. Place; Year.
Smith Y (Ed): Proceedings of the First National Conference on Porous Sieves: 27-30 June 1996; Baltimore. Stoneham: Butterworth-Heinemann; 1996.

Name of the author: Title. Degree thesis. Name of the University, Name of the Department; Year.
Kohavi R: Wrappers for performance enhancement and oblivious decision graphs. PhD thesis. Stanford University, Computer Science Department; 1995.

Name of the authors. Title. Journal short name Year, Volume (Issue): Page numbers.
Ponder B, Johnston S, Chodosh L. Innovative oncology. In Breast Cancer Res 1998, 10:1-72.

Name of the authors: Title. Journal short name, in press.
Kharitonov SA, Barnes PJ: Clinical aspects of exhaled nitric oxide. Eur Respir J, in press.

Tables: We strongly support authors to submit tables in .doc format. Each and every table should be in a separate page and numbered consecutively in Arabic numerals and supplied with a legend. Tables should be self-explanatory without reference to the body. Cells can be copied from an Excel sheet and pasted into a word document, should not embed the Excel files as objects.

Note: PDF format of the article should be requested to submit in a doc format, in order to help in the completion of procedure successfully.

Figures and Figure Legends: Submission of Figures must be only in high-resolution TIFF, and JPEG formats. If you have designed images with separate components on different layers, kindly submit us the Photoshop files. Use Arabic numerals to classify figures and upper case letters for their parts and should be in parentheses (Figure 1). Figures legends should be in numerical order on a separate document. Information given in legends should not be repeated in the body.

Equations (OR) Formulae: Please use Math type for equations. Suggested Equation extraction Methods are Table and Equation Specifications.

Supplementary Material: Figures/Summary diagram included as part of the Supplementary Information (if any). All Supplementary Information is supplied as a single PDF file, where possible. File size within the permitted limits for Supplementary Information.

Acknowledgements: Authors need to provide the funding details and the grant numbers if any.

Peer Review of Manuscript

All the articles/reviews/mini communications/special issues or any other content submitted to our journals are first processed by our editorial team. The topics covered in the content are ensured to meet the minimum journal standards for their quality, validity, novelty, relevance and contribution to the respective field. All the submitted content expected to be in accordance with the guidelines of editorial policy of the journal.

Peer review is planned to select technically original research articles of significant interest in the specified areas within the scope of our journals

Reviewers are expected to assess the novelty of the work, to identify flaws and to suggest improvements accordingly.
Reviewers involved in peer review process are responsible to analyze the validity, novelty of the work and can point out any shortcomings in the paper for further improvements
The articles submitted to our Journals are first processed by our editorial team and ensured that the submission meets minimum Journal norms for relevance, quality and contribution as outlined in our Editorial policy.
If the editorial team finds the paper not appropriate in terms of relevance and/or quality issues, the article might be rejected. Thus, articles that are sent out for review are assumed to meet these basic criteria for publication in our Journals.
The submitting authors and the reviewers are concealed from each other throughout the review process.
Peer review creates awareness of the emerging topics in the current research of area of interest.

Jacobs Journals are organized by Jacobs Publishers LLC company. They are self supported company and they do not get any financial support from any institution or Government. The handling fee received by the company from authors/academia/companies etc being used for the operation and maintenance of the journals in website.

Since it is open access to entire community, company do not receive any subscriptions. Authors need to pay a fair and reasonable handling fee for the processing their articles.

The above charges are levied only after accepting the articles for processing after quality check from our end.

Our regular article processing charges vary from $499 to $2799.

The above charges may vary depending on the various number of edits/modifications/additions/color effects/video additions/more number of pages/ extra alignments etc.

For encouraging students/scholars we are offering special edition for students. The price for students/scholars vary from $199 to $499.


Articles in Press 

September 2017

Volume 3  Issue 1


Research Article

Response of the Bone Marrow Stromal Cells to Osteogenic Drugs in Patients Undergoing Primary Total Hip Arthroplasty

Weiping Ren*, Nancy Jackson, Jeffrey C. Flynn, and David C. Markel

Implant osseointegration relies on the interplay of implant surface and the surrounding bone cells. The purpose of this study was to investigate the in vitro response of the bone marrow stromal cells (BMSCs) to osteogenic drugs in patients undergoing primary total hip arthroplasty (THA). Bone marrow aspirates were obtained from the discarded femoral head in 13 THA patients. The number of STRO-1 and bone morphogenetic protein receptor (BMPR)-expressing cells were measured by flow cytometry. Real-time PCR was used to measure expression of osteogenic relevant genes of BMSCs.

Full textDownload PDF

December 2016

Volume 2  Issue 1



The Double Face of Janus: A Historical Account of the Emergence of Bone Marrow Transplantation

Camilla Scanlan*, Ian Kerridge

History of modern blood and marrow transplantation (BMT) emerged, as is the case with most new biomedical interventions from sustained clinical and scientific research. But BMT also has a much darker antecedent – nuclear power and chemical warfare. It is important that we know the full story of the emergence of BMT for two reasons. The first is that it illustrates how accounts of the history of medicine in  terms of heroes and beneficent progress are simplistic and often erroneous. The second is that it reminds us that biomedical knowledge may arise from human misery and may also cause it.

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Review Article

Endothelial Progenitor Cells (EPCs) – Clinical Implications

Arnon Blum*, Nava Blum

The endothelium is responsible for the homeostasis of the cardiovascular system and other organs by producing and secreting molecular signals, activating and upgrading expression of receptors on many cell surfaces including endothelial cells themselves, a self-perpetuating condition that is accelerating with time until a specific mechanism blocks the signals. Most of the endothelial progenitor cells (EPCs) reside in niches within the bone marrow and are released only “on demand” when a certain trigger is activated – like ischemia or an increase in oxidative radicals or other inflammatory trigger is activated – recruiting them to remote areas of ischemia where they are most needed for regeneration of blood vessels.

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Research Article

Increased Risk for Relapse if ATG is Included in Reduced-Intensity Conditioning HSCT with Sibling Donors

Mats Remberger*, Jonas Mattsson

Hematopoietic stem cell transplantation (HSCT) is an established curative treatment for patients with hematological malignancies, bone-marrow failure syndrome, primary immunodeficiencies, and inborn metabolic disorders. In the early days of HSCT, most patients were treated with high dose myeloablative chemo/radio-therapy (MAC) with the aim to kill most malignant cells and create space for the new marrow.

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Research Article 

Emerging Concepts for Articular Cartilage Regeneration

Luminita Labusca *, Udo Greisser4, Kaveh Mashayekhi

The field of articular cartilage repair attracts considerable interest from the part of basic scientists, bioengineers and medics. Numerous teams are engaged in the quest for finding the most viable and enduring method for restoring a damaged joint surface. However, after several decades of intense research, cartilage diseases still represent an unmet clinical need.

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Case Report

Pomalidomide as Consolidation Therapy after Salvage Autologous Stem Cell Transplant

Mary Steinbach*, Tim Luetkens, Kristen Vinik, Sabarinath Venniyil Radhakrishanan, Djordje Atanackovic

Over the past decade there have been many advances in the treatment of multiple myeloma (MM). However, in the first-line setting, induction treatment followed by high-dose chemotherapy plus autologous stem cell transplant (ASCT) is still considered the standard of care for eligible patients. Regardless of previous treatment and progression history, maintenance therapy has become a mainstay in myeloma treatment.

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December 2015

Volume 1  Issue 2


Review Article

Bioactive Mediators Associated with Mesenchymal Stem Cells-Mediated Immunomodulation

Lukáš Zachar*, Darina Bačenková, Jindrich Soltys, Ján Rosocha

Human mesenchymal stem cells (MSCs) have gained the attention in the field of regenerative medicine and cell therapy due to the low immunogenicity, distinctive immunomodulatory properties and also for the large potential to differentiate into many cell lines with not only mesenchymal origin. Our knowledge of the reparative, regenerative and immunomodulatory properties of MSCs is  advancing. At the present we have a very comprehensible understanding how the MSCs affects the immune system.

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Review Article

Differentiation and Apoptosis inducing Therapy with High-dose Methylprednisolone for non-APL Acute Myeloblastic Leukemia

Gönül Hicsönmez M.D*

Considerable progress has been achieved in the treatment of patients with acute promyelocytic leukemia (APL) by using retinoic acid and/or arsenic trioxide. However, it is generally considered that an effective agent which induces differentiation of myeloid leukemic cells has not been provided for the treatment of patients with other subtypes of acute myeloblastic leukemia (AML). On the other hand, several in vitro studies have shown that certain steroid hormons (dexamethasone, prednisolone, methylprednisolone) induce differentiation of some mouse and human myeloid leukemic cells to macrophages and granulocytes.
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Review Article

Krebs von den Lungen 6 (KL6-): A Potential Predictive Biomarker for Bronchiolitis Obliterans in Pediatric and Young Adult Bone Marrow Transplant

Flatt Terrie*, Dalal Jignesh, Abyankar Sunil, Reddivalla Naresh, Jefferson Melissa, Neville, Kathleen

Bronchiolitis obliterans syndrome (BOS) is a serious complication of allogeneic bone marrow transplant (BMT) that is difficult to diagnose. There is a need for a biomarker to detect BOS in transplant recipients. Krebs von den Lungen-6 (KL-6) is a high molecular weight glycoprotein that is expressed on the epithelial surface of type II pneumocytes and bronchiolar epithelial cells in the lungs. We hypothesized that serum KL-6 levels would be elevated in subjects with known BOS.

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Original Research Article

Functional Reconstruction of Turbinates with Growth Factors and Adipose Tissue in the Treatment of Empty Nose Syndrome

Lino Di Rienzo Businco, Alessia Di Mario*, Mario Tombolini*, Domenico Crescenzi**, Marco Radici**

Empty nose syndrome (ENS) is a devastating complication of turbinate surgery. The management of ENS is challenging and the evidence base for most treatment modalities remains low. In the present study we propose a safe and effective surgical reconstruction treatment based on the use of Platelet Rich Plasma mixed with Adipose tissue (PRL). The PRL is a preparation rich in stem cells and growth factors, taken from the same patient, that has the potential capability to regenerate the volume of the turbinate and to restore the functionality of the mucosa.

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Basic Research Article

Genetic Alterations Acquired During Culture Expansion of MSC Leads to Widespread Tissue Engraftment and Increased Differentiation Potential in Mice

Hanchen Li, Jian Hua Liu, Hao Zhang, Evelyn Kurt-Jones, Stephen Jones, JeanMarie Houghton*

Mesenchymal stem cells (MSC) are currently being tested as treatment for a variety of diseases. We have little information about the changes that occur during isolation and expansion, and the ultimate disposition of MSC in the body. We have shown that MSC isolated from the bone marrow of mice and expanded in culture undergo spontaneous mutations within oncogenes yet retain tri-lineage differentiation potential. Here we define the surface marker expression of these cells and compare it to the marker expression of previously isolated and characterized cultured pluripotent cells.

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August 2015

Volume 1  Issue 1 


Short Communication 

Mechanism of Ventricular Volume Improvement after Autologous Stem Cell Implantation in Acute Myocardial Infarction

Alvaro Merino* MD PhD, Antoni Gaya MD PhD, Cristina Imízcoz RN, Javier Calvo MD PhD, Teresa Jimenez-Marco MD PhD, Enrique Girona-Llobera MD PhD, Ricard Jordá, MD

We tried to obtain a significant number of CD133+ and CD34+ haematologic precursors from systemic circulation by aphaeresis, and analyzed necrosis area reduction by Tc-91 myocardial perfusion scanning and left ventricular diameters by cardiac ultrasound in a group of patients who received stem cell therapy in the first week after a myocardial infarction.

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Directed Differentiation of Late Stage islet Lineages Remains a Knowledge Gap in Pancreatic Endocrine Development

Fang-Xu Jiang*, Grant Morahan

Directed differentiation of human embryonic stem cells(ESCs) and induced pluripotent stem cells (iPSCs) into approximately210 types of functional cells in our body is theultimate goal of regenerative medicine. The latter is a type of new medicine which is to replace/restore those cells lostthrough injury or disease with functional new cells. Type 1and type 2 diabetes mellitus are pandemic metabolic disorders that currently affect approximately 400 million peopleworldwide, characterized by absolute and relative loss of insulin-secreting β cells and hence are candidate diseases for regenerative medicine.

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Research Article

Collagen Nanofibers Induce Spontaneous Osteogenic Differentiation of Rat Bone Marrow Stromal Cells

Therese Bou-Akl*, Rebecca Miller , Pamela VandeVord

Collagen nanofibers have excellent potential for use as scaffolding material for bone tissue engineering. This study evaluated nanofiber sheets formed by electrospinning of type I collagen. Rat bone marrow stromal cells (BMSCs) were cultured, expanded and seeded onto the nanofiber sheets, tissue culture plastic or collagen coated surfaces. Unseeded nanofiber sheets served as controls.

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Review Article

Predictive Factors for the Outcome of Salvage Autologous Stem Cell Transplant in patient with Relapsed Multiple Myeloma

Mohamed Emara*, Ankur Sharma, Sabuj Sarker, Riaz Alvi, Waleed Sabry, Julie Stakiw, Hadi A. Goubran, Mohamed Elemary

Multiple myeloma is one of the most common hematologic malignancies in adults. In the United State, it is estimated that 24,050 patients will be newly diagnosed and 11,090 patients will die of multiple myeloma in 2014. Autologous stem-cell transplant is considered the standard of care for patients less than 70 years of age at time of transplant. Several randomized trials demonstrated the superiority of autologous stem-cell transplant over conventional chemotherapy in terms of the response rate and event-free survival. However, the median duration of response after this  procedure does not exceed three years, and almost all patients ultimately relapse.

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Research Article

An Efficient Method for Rapid Establishment of Fibroblast-Like Cells from Horse Subcutaneous Adipose Tissue

M. Quamrul Islam*

Adipose-tissue derived stromal cells (ADSCs) are easily obtainable multipotent mesenchymal stem cells capable of differentiation into various cell lineages making it an attractive cell source for regenerative medicine. ADSC is generally isolated from subcutaneous adipose tissue by enzymatic digestion of biopsies followed by removal of undigested tissues and seeding of the dissociated cells onto plastic. This is an inefficient procedure where only a tiny fraction of cells are established in culture and rest of the cells are lost.

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