A mini review on Paclitaxel producing Fungal Strains

Review Article

A mini review on Paclitaxel producing Fungal Strains

*Corresponding author: Tiwari k, IMS and FHLS, Management and Science University, Malaysia.

Abstract

Since the discovery of Penicillin by Sir Alexander flemming The new era of antibiotic producing fungi came into the picture. Paclitaxel is an anticancerous compound and it is widely accepted in hospitals and clinics. Recently a large number of fungi are potential paclitaxel producers were harnessed. In this mini review paclitaxel producing fungal strains are discussed in detail

Keywords: Paclitaxel; Potentialistic fungal strains; Anti cancerous compound

Introduction

There is a need of natural products all over the world. Synthetic drugs possess large number of side effects, therefore the scientific world started focusing on natural products now a days. The drugs of plant origin harnessed at maximum level in the past. New strategies and concepts to be developed and new fungal strains must be discovered for the drug production. Paclitaxel is an anti-cancerous compound produced by various endophytic fungal strains and yew tree. This compound is found in yew trees and these plants usually destroyed to extract paclitaxel in recent years [1-7]. So if the new endophytic fungal strains discovered, which are potentialistic paclitaxel producer at bioprocess level, can be the game changer.

Why Paclitaxel of Fungal Origin

The limitation and disadvantages of paclitaxel from plant origin especially yew trees are that the large number of plants destroyed and these plants grown again to harness the compound. Which is a time process [1-7] Scientist therefore switching to explore the fungal strains which are potentialistic paclitaxel producers.[8].Since natural production of compound from the endophytic fungal strains is an organic process that is why there will not be any side effect. This is the major idea in the researchers mind. A large number of fungi are potentialistic paclitaxel producers listed below [1-7] (Table 1).

 Future Research and Challenges

In the coming future the potentialistic paclitaxel producing fungal strains at bioprocess level will be identified at large scale and patented. But still there are certain challenges or bottleneck to obtain high yield of paclitaxel from the fungal strains for example the genes or loci to be identified, their expression and regulation to be discovered in-vitro.

Reference:

1 Zaiyou J, Li M, Xiqiao H. et.al. An endophytic fungus efficiently producing paclitaxel isolated from Taxus wallichiana var. mairei Medicine. Medicine 2017;96(27):e7406.

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Frense D .Taxanes: perspectives for biotechnological production. Appl Microbiol Biotechnol 2007;73: (6):1233–1240.

Gangadevi V, Muthumary J. A  novel endophytic taxol-producing fungus Chaetomella raphigera from a medicinal plant, Terminalia arjuna. Appl Biochem Biotechnol 1isolated  2009;58:(3)1599–0291.

8  Gangadevi V, Muthumary J. A . Taxol determination from Pestalotiopsis pauciseta, a fungal endophyte of a medicinal plant. Chin J Biotech  2008; 24:(8)1433–1438.      

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