Volume 3 Issue 1
Exuberant Reaction of Facial Keloid in Response to Imiquimod 5% Cream
Robert Hoopes1, Patrick M. Veerkampn2, Jeffrey B. Travers*1,2
A 62-year-old male with a keloid presented to our clinic with extensive overlay of a minimally tender yellow thick adherent crusted plaque on his right cheek (Figures 1a and 1b). The patient stated he was prescribed imiquimod 5% cream and had been applying this to his keloid three days per week for the past 18 weeks. The patient stated he noticed the crusting within eight weeks after he started using the imiquimod 5% cream but continued application as instructed.
Postmenopausal Skin Aging – Exploring the Significance of Estrogen – Gut Microbiota Axis
Nicole C. Sikora1 and Marek K. Dobke1*
Skin aging is a complex biological process influenced by multiple intrinsic (genetic, cellular metabolism, hormonal and general metabolic processes) and exogenous or extrinsic (chronic light exposure, pollution, ionizing radiation, chem- icals, toxins) factors. Intrinsic factors will change the biochemistry of tissues by multipronged effect including alteration of gut microbiota and the compounds they secrete. Specifically, the increase in levels of estrogen and progesterone that have long been considered one of the principal factors regulating skin aging and exerting anti-aging effects on the skin.