Letter to the Editor
Biomarkers for Chagas Disease
Corresponding author: Prof. Vitorino M Santos, Estrada do Contorno do Bosque s/n, Cruzeiro Novo, Zip Code: 70630-900, Brasília-DF, Brazil, Tel: 55-61 39662103; E-mail: email@example.com
…Very important goal for researches about Chagas disease are reliable tools indicative of infection, before detectable pathology process [1-4]. We read the manuscript of Pinho and Antas entitled Biomarkers for neglected Chagas disease where the eminent authors briefly, but clearly, highlighted the role of these necessary tools for diagnostic and therapeutic purposes . They also properly commented about major hurdles and challenges involving the routine utilization of biomarkers to assess the risk of disease among the more commonly affected individuals, who live in lowincome areas of Latin American countries [1,4]. Interestingly, they presented a new classification of biomarker candidates – plasmatic, antigenic, genetic, and management related; in addition, the major practical advantages and eventual weaknesses of each categorized biomarker were focused . Worthy of note are the parasite antigens detected by a correlated ELISA test, and involving highly specific ligands – aptamers. These circulating biomarkers can be found during the acute and the chronic phases of human and experimental infections [1,2]. We would like to address additional comments based on some other recent publications and our previous experimental studies.…Keating et al, evaluated 22 biomarkers related to cardiomyopathy, with the aim to distinguish Chagas disease clinically active from asymptomatic infections, and high titers of IFN-y, IL-6, IL-10, TNF-α, CK-MB, troponin, myoglobin, and VCAM were found in advanced heart disease. However, NTproBNP and T. cruzi PCR status were considered most predictive of disease; therefore, they would be good additional tools to clinical and imaging procedures for disease staging in the routine practice .
most of the infected populations.
1.Pinho RT, Antas RZ. Biomarkers for the neglected Chagas disease: how remarkable! J J Biomark. 2015, 1(1): 006.
2.Keating SM, Deng X, Fernandes F, Cunha-Neto E, Ribeiro AL et al. Inflammatory and cardiac biomarkers are differentially expressed in clinical stages of Chagas disease. Int J Cardiol. 2015, 199: 451-459.
3.Pinazo MJ, Thomas MC, Bustamante J, Almeida IC, Lopez MC et al. Biomarkers of therapeutic responses in chronic Chagas disease: state of the art and future perspectives. Mem Inst Oswaldo Cruz. 2015, 110(3): 422-432.
4.Porrás AI, Yadon ZE, Altcheh J, Britto C, Chaves GC et al. Target product profile (TTP) for Chagas disease pointof- care diagnosis and assessment of response to treatment. PLOS Negl Trop Dis. 2015, 9(6): e0003697.
5.dos Santos VM, de Lima MA, Cabrine-Santos M, de Stefani Marquez D, de Araujo Pereira G et al. Functional and histopathological study of the pancreas in hamsters (Mesocricetus auratus) infected and reinfected with Trypanosoma Cruzi. Parasitol Res. 2004, 94(2): 125- 133.
6.dos Santos VM, de Lima MA, Cabrine-Santos M, Marquez Dde S, Reis Md, Pereira Gde A et al. Pancreatic hepatocytes in hamsters (Mesocricetus auratus) infected with Trypanosoma Cruzi. Exp Parasitol. 2002, 100(2):103- 111.
7.dos Santos VM, Teixeira Vde P, da Cunha DF, da Cunha SF, Monteiro JP et al. [Pancreatic anatomopathologic changes in chronic chagasic woman. Preliminary data]. Arq Gastroenterol. 1999, 36(3): 127-132.