Body Mass Profiles among Younger and Older Hip Osteoarthritis Cases Requiring Surgery: Do this Matter Clinically?
Running title: Hip osteoarthritis and body mass
Understanding the factors that influence the onset and progression of hip osteoarthritis, a highly painful disabling disease with no known cure, is currently of high importance given that one in four adults will develop this condition in his or her lifetime . One potentially preventable factor strongly linked to several forms of osteoarthritis is obesity. Yet, this is controversial with respect to osteoarthritis of the hip.
For example, although Murphy et al. , and Grotie et al.  found no association between body mass and the lifetime risk for hip osteoarthritis, Holliday et al.  showed becoming overweight early on in life increased the risk of developing hip osteoarthritis. Moreover, even though Kessler et al.  found body weight had no influence on short term outcomes of hip replacement surgery, Chee et al.  who examined the five year outcomes of patients receiving hip replacement surgery, found those who were morbidly obese had higher rates of complications than those who were non-obese, a similar finding to Houdeck et al. . Lubbeke et al.  too found those osteoarthritis cases who were overweight and underwent hip joint arthroplasty surgery had an increased rate of adverse health outcomes.
To provide some additional data to support or refute the role of obesity in the context of hip osteoarthritis, we elected to carefully examine and detail the body weight characteristics of a reasonably large sample of community dwelling adults with end-stage hip osteoarthritis requiring surgery.
We also conducted sub category age related observations of the distribution of body weights among the sample, conjecturing that if obesity is a risk factor for severe hip osteoarthritis, a high proportion of younger cases in such a sample would exhibit high rather than normal or low body weights, as represented by a body mass index (BMI) higher than 25.
Moreover, we conjectured that if body weight impacts the severity or progression of hip osteoarthritis, those experiencing severe complications would exhibit high rather than normal body weights, on average.
Finally, because obesity is linked to metabolic syndrome, we anticipated that obese hip osteoarthritis cases, that is those with BMIs greater than 29.9 would be more likely than not to exhibit one or more of these diseases than those who were normal weight or underweight.
To examine these premises objectively, the present analysis examined:
1. The body mass distribution patterns among the present cohort of severely disabled hip osteoarthritis cases requiring primary or secondary surgeries.
2. The body mass distribution patterns among those younger and older than 65 years of age.
3. The body mass distribution patterns among those with no prior surgical history, and those requiring surgery for revision or severe post-surgical complications.
Selected analyses were also conducted to examine gender related body mass distribution patterns, as well as metabolic syndrome related patterns of presentation.
Materials and Methods
Records of a sample of 1040 patients hospitalized for some form of hip replacement or revision surgery due to the presence of severe disabling end-stage hip osteoarthritis of one or both hips collected prospectively as part of an approved parent study of hip joint surgical outcomes were examined.After excluding those with rheumatologic health conditions, as well as those with acute hip fractures, there were 997 available records of men and women between 23-89 years of age, among whom 823 had no history of prior surgical complications requiring either revision or restorative secondary surgeries. In addition to demographic data, body mass indices, and evidence of diabetes, cardiovascular disease, depression, and numbers of comorbid health conditions were extracted from the records. Body mass index (an indicator of body mass derived from the formula weight.height2), was categorized into underweight (BMI less than 20), normal weight (BMI 20-24.9),overweight (BMI 25-29), and obese (>29) categories. Type of surgical condition was categorized as unilateral primary hip joint replacement, bilateral primary hip joint replacement, revision replacement surgery with no complications, revision surgery with severe complications such as infection, dislocation, or periprosthetic fractures. Data were systematically entered into SPSS version 17.0 files to examine trends in the data as regards body mass index, along with selected demographic and clinical variables using chi-square tests, cross-tabulations, and analysis of variance. An a priori significance level of 0.05 was adopted.
The baseline descriptive characteristics of the sample are shown in Table 1. The mean age of the sample was 65.5+12.98 years (range 23-94) and 57% were women, and 42% were men.
The mean body mass index of the sample of 27.6+5.7 (range 15-68, median 27), showed most or 67% were overweight, on average, and males were more likely to be overweight, obese, or excessively obese with a body mass index>40 than females (p=.001). The 390 cases under age 65 tended to be heavier on average than those 599 cases over age 65 (p=.001)(28.8+6.4 vs 26.9+5.2).The correlation between body mass index and age was an inverse one, r=.18; p=.001, suggesting that those who were younger tended to be heavier than those who were older. Unsurprisingly, among those in the excessively obese range (BMI > 40), 23% had diabetes compared to 5% among those in the overweight or moderately obese categories, and 43% of these excessively obese cases had comorbid hypertension histories (p < 001). Among the 39 excessively obese cases, 23 or about 54% were 65 years or younger.
The relationship between gender and body mass, and between age and body mass category is shown in Tables 2 and 3. As indicated, those categorized as obese were generally younger than those who were not, and males tended to present with higher overall rates of obesity, in general, than females.
In terms of body mass distributions among the sub-group of patients undergoing primary or secondary surgeries, those who experienced serious complications following prior hip surgery tended to be heavier on average than those with no complications, or those requiring standard revision procedures (F=2.78; df=3; p=.04). Conversely, those in the normal body mass or underweight category experienced proportionately fewer severe complications than those who were obese p=.001) (See Table 4). Those requiring bilateral hip joint replacement surgery were almost 10 years younger than those requiring any other form of surgery (p=.001), and 62.5% of those requiring surgery for complications such as periprosthetic fractures were male (p=.001).
Among those with 3 comorbid health conditions, hypertension, cardiovascular disease, and diabetes, no subject was observed to be at a healthy weight. Of those with BMIs greater than 40, 9% were healthy, while almost 28% had a metabolic syndrome related comorbid health condition (p=.025). Among the 44 cases with a diabetes diagnosis, almost 50% were obese, and 19.1% were morbidly obese (p=.001). Being overweight or obese was related to the presence of a high blood pressure diagnosis (p=.001), but not to cardiovascular health (p=.117).
Although the relationship between overweight and hip joint osteoarthritis is not definitive, results of this present analysis suggest overweight is an important hip joint osteoarthritis correlate.
That is, obesity as defined by a body mass index of 29.9 or higher was a consistent feature of this present cohort, especially among those younger than 65 years of age. Moreover, consistent with Changulani et al. , those in the morbidly obese range were almost 10 years younger on average than those in the normal weight category, and those with higher body weights were more likely to experience adverse surgical outcomes than those who were not. The finding that younger cases with no other identifiable disease cause had high rates of obesity, especially morbid obesity rates, is consistent with findings of Tai et al.  and Guetner et al. . As in Guetner et al.’s study, it appears younger adults, especially those who suffer from morbid obesity may be quite prone to developing osteoarthritis in both hips, as well as other disabling health conditions such as diabetes and cardiovascular disease. They may also require early hip joint replacement surgery, while incurring an increased risk of poor surgical outcomes, due to their lack of physical activity and possible hormonal imbalances that produce poorer bone quality .
Liu et al.  reported 27% of hip replacements in middle age women were attributable to obesity, as outlined in 2007. Although our data do not support that of Jacobsen and Holm  who found total hip replacement was predicted solely by body mass indices at baseline, the present data do support a strong obesity influence in this disease, with similar rates to Liu et al.  of approximately 25% for women. This relationship currently appeared even stronger for men, where approximately 36% were obese, and being obese was especially evidenced among those men 65 years of age or younger.
In line with Vinequerra et al.  who examined 149 patients over 5 years for risk of future total hip replacement, and found a three-fold risk in those with body mass indices greater than 27, almost 70% of those younger than 65 years of age in the present study had body mass indices greater than 25, when considered as a whole. That is, they had an average BMI of 28.8+6.3, and 64.1% of those in the excessively obese category were 65 years of age or less versus 35.9% who were older than 65 years of age. As well, younger cases experienced the same rate of severe complications as the older cases, even though Wallace et al.  reported no similar major adverse impact of body mass index on risk of post-operative complications six months after total hip replacement surgery, as did Tai et al.  after 10 years, but this group did not examine morbidly obese patients cases independently.
While Grotle et al.  found no association between body mass and hip osteoarthritis, obesity, an independent predictor of pain , can undoubtedly place excess biomechanical stress on the hip joint. It can also increase chances of adopting a sedentary lifestyle, and hence not unsurprisingly, greater body weight and body mass index during early and middle adulthood .
Since being overweight could render individuals of any age subject to abnormal hip joint loading forces that can initiate early joint destruction processes along with increases in pro-inflammatory enzymes that degrade cartilage matrix , hip joint destruction may not depend solely on age. Moreover, associated high rates of pain, as well as joint destruction and postural changes in those who are excessively obese can be expected to impact the pathogenesis of hip joint osteoarthritis both before and after surgery more profoundly than non obese situations [18, 19]. Alternately, the constellation of obesity, immobility and pain can independently raise the risk for hip joint osteoarthritis, and its disability.
Although a causal link between obesity and hip joint osteoarthritis cannot be confirmed on the basis of this retrospective cross sectional study, and its small sample size and makeup, plus limited mode of assessing body mass, it is difficult to refute the hypothesis that obesity can independently impact the onset of hip osteoarthritis and its severity. The results do however comport with others such as Guenther et al. , and hence to more ably support this hypothesis, prospective studies that utilize underwater weighing and bioelectrical impedance measures of body mass along with radiographic scans may be helpful.
Having a high body mass appears more characteristic than not of individuals hospitalized for purposes of total hip replacement, revision surgery, or severe complications from prior surgery. Whether this is a consequence of the disease, rather than a cause or risk factor it is important to consider:
1. A high percentage of end stage hip osteoarthritis cases are obese, especially when compared to current publicized rates among adults of approximately 33% .
2. Forty percent of those younger than 65 years of age, and approximately 24 percent of those 65 years of age or older were categorized as being obese, suggesting obesity is not necessarily a consequence of the duration of the disease.
3. Men were more likely to be obese, as well as overweight in this sample compared to women, especially in the younger age group.
4. Excessively obese cases with BMIs > 40 were more likely to be under age 65 than over 65 years of age, and were equally represented by men and women.
5. Being hospitalized for a severe post-surgical joint replacement complication was associated with being excessively obese, especially among males.
6. Being overweight or obese was statistically correlated with the presence of one or more metabolic health condition, regardless of gender, and no subject with three comorbid conditions was reported to be at a healthy weight.
In accord with Guenther et al.  and Cimmino et al.  who implied obesity is likely to heighten the osteoarthritis disease severity, pain, and dysfunction, it appears reasonable to conclude that excess body mass can raise the risk for early onset of hip joint osteoarthritis, plus early referral for hip osteoarthritis surgery. Regardless of age , excess obesity can also increase the likelihood of post-surgical complications and smaller than desirable outcome benefits. It can increase readmissions rates, and need for reoperations, plus surgical duration and hospital length of stay . Hence despite the limitations of an observational study for pinpointing causation, along with the present mode of assessing obesity, in absence of a cure for hip osteoarthritis, this present study implies efforts to minimize the onset and progression of obesity across the lifespan may prove highly beneficial, despite the lack of consensus of a distinct correlation of these factors .
This lack of consensus is however declining, and past lack of clarity on this issue may have stemmed in part, from the fact that in some earlier studies, obesity was not the prevalent problem it is today [eg 26], and the magnitude of obesity may have been lower, and the population not as sedentary as a whole. Consequently, there was less distinction in older case control studies between subjects, in the context of body mass estimates and a lower likelihood of a connection between these variables. The tendency to operate on much younger patients today, may also reveal new trends in the risk attributable to obesity versus age in the case of hip osteoarthritis. Newer data are clearly more consistent in identifying a reasonably strong association between excess body mass and the onset and progression of hip osteoarthritis [15, 27, 28], especially the early onset of this condition. [29, 30]. Weight gain also clearly raises the risk of later total hip replacement surgery , and this relationship is stronger in younger men and women, and absent in older men and weaker in older women . Since the prevalence of overweight is increasing in the general population , and body mass is a modifiable risk factor , the need to focus on weight control in early life, as well among those who are already diagnosed with hip osteoarthritis is clearly of potential clinical significance. This primary prevention approach may especially help to attenuate the immense personal burden experienced among young people with hip osteoarthritis , as well as older cases who are at increased risk of adverse events after surgery [33, 34], plus those with a BMI of 35kg.m-2, and comorbid health conditions . Indeed, despite past conjecture concerning the importance of obesity as a hip osteoarthritis risk factor, it is our view that this present analysis, plus an increasing number of current as well as past studies [eg 38] are providing compelling evidence that obesity prevention and intervention is imperative in any meaningful effort to stem the tide of increasing disability attributable to hip osteoarthritis anticipated in the aging population.
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