Current Edition

Volume 4 Issue 2


Case Report

Pomalidomide as Consolidation Therapy after Salvage Autologous Stem Cell Transplant

Mary Steinbach*, Tim Luetkens, Kristen Vinik, Sabarinath Venniyil Radhakrishanan, Djordje Atanackovic

Over the past decade there have been many advances in the treatment of multiple myeloma (MM). However, in the first-line setting, induction treatment followed by high-dose chemotherapy plus autologous stem cell transplant (ASCT) is still considered the standard of care for eligible patients. Regardless of previous treatment and progression history, maintenance therapy has become a mainstay in myeloma treatment.

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Research Article

Response of the Bone Marrow Stromal Cells to Osteogenic Drugs in Patients Undergoing Primary Total Hip Arthroplasty

Weiping Ren*, Nancy Jackson, Jeffrey C. Flynn, and David C. Markel

Implant osseointegration relies on the interplay of implant surface and the surrounding bone cells. The purpose of this study was to investigate the in vitro response of the bone marrow stromal cells (BMSCs) to osteogenic drugs in patients undergoing primary total hip arthroplasty (THA). Bone marrow aspirates were obtained from the discarded femoral head in 13 THA patients. The number of STRO-1 and bone morphogenetic protein receptor (BMPR)-expressing cells were measured by flow cytometry. Real-time PCR was used to measure expression of osteogenic relevant genes of BMSCs.

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