Current Edition

Volume 4

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Short Communication

Nicotinamide and Nicotinoyl-Gaba in Prevention of Experimental Diabetic Neuropathy

Kuchmerovska T.M. 1*, Tykhonenko T.M.1, Guzyk M.M.1 , Tykhomyrov A.O.1, Yanitska L.V.2

Diabetic neuropathy is associated with development of cognitive dysfunction and structural and metabolical alterations in brain. We aimed to evaluate the potential benefit of nicotinamide (NAm) and nicotinoyl-GABA (N-GABA), conjugate of nicotinic acid and GABA, administration on alterations in the expressions of nuclear factor kappa B (NF-kB), neuronal nitric oxide synthase (nNOS) and vascular endothelial growth factor (VEGF) in brain of diabetic rats.

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Review Article

Leptin/Adiponectin Ratio is Progressively Elevated in Pre-diabetic to Type 2 Diabetic
African American Adults

Karan Chawla a,c, Maurice B. Fluitta f, Alicia Dillard a,c, Gail Nunlee-Bland b,c, Kanwal K. Gambhir a,c*

Individuals with T2DM or pre-diabetes encounter a decrease in plasma adiponectin and increase in plasma leptin. However, very few studies have investigated the levels of these adipokines in African American diabetic and pre-diabetic patients.

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Research Article

Association between obesity and inflammation among diabetic polyneuropathy patients

Tayebeh Mottaghi1, Fariborz Khorvash2, Mohammadreza Maracy3, Farzin Khorvash4, Majid Kherirollahi5, Gholamreza Askari6

Inflammation is defined as body tissues response to harmful stimuli. Obesity-related inflammation leads to increased risk chronic diseases including diabetic polyneuropathy (DPN).  The present study was performed to determine association between body mass index (BMI) and inflammatory markers including erythrocyte sedimentation rate (ESR) and C−reactive protein (CRP).

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Research Article

Peripheral arterial disease and its predictors in type 2 diabetic subjects in nnewi, south-eastern nigeria

Oguejiofor Ogonna Celestine1, Onwukwe Chikezie Hart1, Ezeude Chidiebele Malachy1, Okonkwo Ejike Kenneth1, Nwalozie Justin Chibueze1, Odenigbo Charles Uzoma2, Oguejiofor Charlotte Blanch3

Peripheral arterial disease (PAD) is a cause of foot disease in type 2 diabetes mellitus (T2DM) subjects. Data on associated predictors of PAD in Nigerian T2DM subjects are scanty, especially from South-Eastern Nigeria. This study aims to evaluate the prevalence and predictors of PAD in T2DM subjects in Nnewi, South-Eastern Nigeria.

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Research Article

The Influence of Hashimoto’s Thyroiditis Lymphocytic Infiltration in BRAFV600E Mutation Positive Papillary Thyroid Carcinoma

Kuchmerovska T.M. 1*, Tykhonenko T.M.1, Guzyk M.M.1 , Mi Kyung Shin*. Jeong Won Kim

PTC is the most common thyroid cancer and has been increased in number, worldwide[1]. HT is the most frequently found autoimmune thyroid disease, and around two percent of the general population suffer from this disease[2]. Ever since Dailey and his co-workers first discovered the relationship between HT and PTC in 1955, scholars started to pay increasing attention to this topic [3]. However, the pathogenesis of PTC in HT patients still remains unclear.

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Case Report

Improvement of glucose variability by continuation of Low-Carbo meal

Hiroshi BANDO1,2*, Takako ABE2, Miwako NAKANISHI2, Osami WATANABE2,and Hiroe KAWANO2

Recently, there has been serious medical and social problems worldwide. It is acute increase of type 2 diabetes mellitus (T2DM). The number of T2DM was approximately 385 million in 2014, and will increase to 592 million by 2035 [1,2]. Consequently, effective and successful treatment for T2DM has been in discussion for years, including diet therapy, exercise therapy, anti-diabetic agents and insulin therapy [3].

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Case Report

Subclinical Hyperthyroidism Progressing to Graves’ disease After Excision of a Non-Function Pituitary Adenoma: A Case Report

Husain Taha Radhi ,1* Mahmood Al Saeed ,2 Mohammed Al Barni ,3 Ebtihal Al ,4 yusuf, and Eman Al Basri,5

Non-functioning pituitary adenomas (NFPA’s) are common type of pituitary tumors. They usually present late with compression symptoms. Graves’ disease is an autoimmune disease affecting the thyroid hormone receptors in the thyroid gland. The relationship between these two pathologies is extremely rare and to our knowledge, has not been
described in the literature yet. In this report we describe a case of a patient who was diagnosed with a NFPA and found out to have Graves’ disease after resection of the Adenoma.

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Editor Note

Diabetes and Endocrinology

M. Sailaja1*

The presented work focuses on the endocrine glands, its secretions and their coordination with metabolism and reproduction. It is a complete study, which includes symptoms, causes, pathophysiology, diagnosis, treatment and prevention of diabetes and the study of new techniques in the field of diabetic research like organ transplantation, tissue regeneration and therapeutic innovations of diabetes.

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