Volume 1 Issue 2
Acute Ingestions of Acetaminophen Combination Products Resulting in Marked Bactrian Pharmacokinetics
Jean CY Lo*1, Stephen Thornton 2, Richard F. Clark
Acetaminophen (APAP) is a widely available analgesic and antipyretic that is presented in numerous over the counter and prescription preparations, frequently as part of a combination product with an antihistamine or an opioid. The ubiquity of acetaminophen-containing products explains why it is among the most commonly encountered substances involved in overdoses reported to the AAPCC’s National Poison Data System .
Target Specific Cancer Treatment with Carbon Monoxide Releasing Molecules
Carbon monoxide (CO) is a colorless, odorless, and tasteless gas which has been defined as “silent killer” for a long time. CO has strong affinity for hemoglobin, and CO-hemoglobin (carboxyhemoglobin) complex inhibits oxygen delivery to tissues by red blood cells . Apart from this poisoner effect, the therapeutic potential of CO has been extensively evaluated in pathogenesis of many diseases. CO is naturally produced by heme oxygenase 1 and 2 (HO-1 and HO-2) activity in tissues.
Adriamycin’s Hepatotoxic Effect Associated With Local Renin Angiotensin System
Celal GUVEN*1, Eylem TASKIN 2
Cancer patient’s number is going to scale up every year. Adriamycin (ADR) is one of the most effective anticancer drug against to solid tumors. Unfortunately, the drug has a undesired side effect on some tissue including heart, liver, kidney, pancreas. Although many studies found that ADR’s toxic effect relate to oxidative stress, the exact molecular mechanisms underlying of its side effect has not completely understood.