Volume 1 Issue 1

Volume 1 Issue 1 

_________________________________________________________________________________________________

Research Article
Neuron-Microglia Communication Delivered CRFR1 Phosphorylation during Long-Term Morphine Treatment
Hui Zhao*, Han-Wei Huang, Gen-Cheng Wu 

Morphine-mediated AC activation requires Src kinase, which was postulated to be responsible for morphine tolerance and dependence. Currently, we demonstrated that following long-term morphine treatment and subsequent naloxone precipitation, microglia was activated, which appeared to be obligatory for CD44 expression and production of IL-1beta, iNOS, MCP-1, MIP-1alpha, MIP-1beta, and TNF-alpha. Significantly, neuronal CRFR1 could be phosphorylated at serine 396 by c-Src-RSK1 signaling, which was subjected to microglia activation and preferentially strengthened AC5 up-regulation.

Full textDownload PDF

_________________________________________________________________________________________________

Editorial
Pyrimidine Derivative Compounds as HSP90 Inhibitors in Cancer Treatment
Yusuf TUTAR* 

Pyrimidine scaffold is an important member of bioactive heterocyclic compounds which are also used in the treatment of cancer, infection diseases, diabetes, gastrointestinal diseases, and cardiovascular diseases. Therefore, pyrimidine ring has been significant structure for synthetic organic chemists and drug designers for many years. Pyrimidine derivatives interact with a large number of intracellular targets in human. Especially, pyrimidine derivative compounds inhibit Heat Shock Protein 90 (Hsp90) chaperone activity, and interrupt proliferation in cancer cell.

Full textDownload PDF