Volume 1 Issue 2

Volume 1  Issue 2

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Research Article

Collagen Nanofibers Induce Spontaneous Osteogenic Differentiation of Rat Bone Marrow Stromal Cells

Therese Bou-Akl*, Rebecca Miller , Pamela VandeVord

Collagen nanofibers have excellent potential for use as scaffolding material for bone tissue engineering. This study evaluated nanofiber sheets formed by electrospinning of type I collagen. Rat bone marrow stromal cells (BMSCs) were cultured, expanded and seeded onto the nanofiber sheets, tissue culture plastic or collagen coated surfaces. Unseeded nanofiber sheets served as controls.

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Review Article

Predictive Factors for the Outcome of Salvage Autologous Stem Cell Transplant in patient with Relapsed Multiple Myeloma

Mohamed Emara*, Ankur Sharma, Sabuj Sarker, Riaz Alvi, Waleed Sabry, Julie Stakiw, Hadi A. Goubran, Mohamed Elemary

Multiple myeloma is one of the most common hematologic malignancies in adults. In the United State, it is estimated that 24,050 patients will be newly diagnosed and 11,090 patients will die of multiple myeloma in 2014. Autologous stem-cell transplant is considered the standard of care for patients less than 70 years of age at time of transplant. Several randomized trials demonstrated the superiority of autologous stem-cell transplant over conventional chemotherapy in terms of the response rate and event-free survival. However, the median duration of response after this  procedure does not exceed three years, and almost all patients ultimately relapse.

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