Volume 1 Issue 2
Bioactive Mediators Associated with Mesenchymal Stem Cells-Mediated Immunomodulation
Lukáš Zachar*, Darina Bačenková, Jindrich Soltys, Ján Rosocha
Human mesenchymal stem cells (MSCs) have gained the attention in the field of regenerative medicine and cell therapy due to the low immunogenicity, distinctive immunomodulatory properties and also for the large potential to differentiate into many cell lines with not only mesenchymal origin. Our knowledge of the reparative, regenerative and immunomodulatory properties of MSCs is advancing. At the present we have a very comprehensible understanding how the MSCs affects the immune system.
Differentiation and Apoptosis inducing Therapy with High-dose Methylprednisolone for non-APL Acute Myeloblastic Leukemia
Gönül Hicsönmez M.D*
Considerable progress has been achieved in the treatment of patients with acute promyelocytic leukemia (APL) by using retinoic acid and/or arsenic trioxide. However, it is generally considered that an effective agent which induces differentiation of myeloid leukemic cells has not been provided for the treatment of patients with other subtypes of acute myeloblastic leukemia (AML). On the other hand, several in vitro studies have shown that certain steroid hormons (dexamethasone, prednisolone, methylprednisolone) induce differentiation of some mouse and human myeloid leukemic cells to macrophages and granulocytes.
Krebs von den Lungen 6 (KL6-): A Potential Predictive Biomarker for Bronchiolitis Obliterans in Pediatric and Young Adult Bone Marrow Transplant
Flatt Terrie*, Dalal Jignesh, Abyankar Sunil, Reddivalla Naresh, Jefferson Melissa, Neville, Kathleen
Bronchiolitis obliterans syndrome (BOS) is a serious complication of allogeneic bone marrow transplant (BMT) that is difficult to diagnose. There is a need for a biomarker to detect BOS in transplant recipients. Krebs von den Lungen-6 (KL-6) is a high molecular weight glycoprotein that is expressed on the epithelial surface of type II pneumocytes and bronchiolar epithelial cells in the lungs. We hypothesized that serum KL-6 levels would be elevated in subjects with known BOS.
Original Research Article
Functional Reconstruction of Turbinates with Growth Factors and Adipose Tissue in the Treatment of Empty Nose Syndrome
Lino Di Rienzo Businco, Alessia Di Mario*, Mario Tombolini*, Domenico Crescenzi**, Marco Radici**
Empty nose syndrome (ENS) is a devastating complication of turbinate surgery. The management of ENS is challenging and the evidence base for most treatment modalities remains low. In the present study we propose a safe and effective surgical reconstruction treatment based on the use of Platelet Rich Plasma mixed with Adipose tissue (PRL). The PRL is a preparation rich in stem cells and growth factors, taken from the same patient, that has the potential capability to regenerate the volume of the turbinate and to restore the functionality of the mucosa.
Basic Research Article
Genetic Alterations Acquired During Culture Expansion of MSC Leads to Widespread Tissue Engraftment and Increased Differentiation Potential in Mice
Hanchen Li, Jian Hua Liu, Hao Zhang, Evelyn Kurt-Jones, Stephen Jones, JeanMarie Houghton*
Mesenchymal stem cells (MSC) are currently being tested as treatment for a variety of diseases. We have little information about the changes that occur during isolation and expansion, and the ultimate disposition of MSC in the body. We have shown that MSC isolated from the bone marrow of mice and expanded in culture undergo spontaneous mutations within oncogenes yet retain tri-lineage differentiation potential. Here we define the surface marker expression of these cells and compare it to the marker expression of previously isolated and characterized cultured pluripotent cells.