Volume 2 Issue 1
Pc 4 Conjugated Iron Oxide Nanoparticles as Photodynamic Therapeutic Carriers
Michael Hilgendorff, Ana Aljarilla, Francesca Setaro, Andrés de la Escosura, Tomás Torres, Petri Mäkinen, Ervin Nippolainen, Seppo Ylä-Herttuala, Jakub Dalibor Rybka, Michael Giersig*
Magnetite nanoparticles have been chosen in the CosmoPHOS-nano project as one of three types of phthalocyanine conjugated carrier particles because of their magnetic properties and biocompatibility. The main challenge was the dye-conjugation of the nanoparticles. This article does not focus on the magnetic properties but rather on the possibilities of using these conjugates in the Life- Science. Monodisperse magnetite nanoparticles, 15 nm in diameter, were prepared by thermal decomposition of iron(III) oleate in high boiling octadecene in presence of oleic acid as a stabilizer.