Hepatic Adaptations to a High Fat Diet in the MRL Mouse Strain are Associated with an Inefficient Oxidative Phosphorylation System
Ahlke Heydemann*,Magdalis González-Vega, Tirsit K. Berhanu, Aaron J. Mull,RagavSharma, and Jenan Holley-Cuthrell
The MRL mice are resistant to a 12-week high fat diet (HFD) feeding protocol, with the proximal cause being an increased basal pAMPKT172 expression in the skeletal muscle. Here, we test if this lack of pathology extends to the liver at both the tissue and cellular levels and its correlation to pAMPKT172 levels. MRL and B6 mice were subjected to 12 weeks of diet intervention and tissues were either fixed for histology or snap-frozen for further processing (n= 3-6, per group).
miRNA-15a, miRNA-15b, and miRNA-499 are Reduced in Erythrocytes of Pre-Diabetic African-American Adults
Maurice B. Fluitt, Namita Kumari, Gail Nunlee-Bland, Sergei Nekhai, Kanwal K. Gambhir*
The genetics of T2DM is complex and not clearly understood. The search for diabetes genes and risk markers is complicated by the heterogeneity of the metabolic disease. Genomewide association studies (GWAS) have identified several genetic variants in association with T2DM. However, since the first T2DM GWAS study, identified genetic variants have been modestly associated with T2DM and account for only about 10% of genetic risk. Further complicating the identification of genetic biomarkers for T2DM is ethnicity, as genetic variants may be ethnic specific. Additional studies to identify risk markers in the African-American population are needed.