Editor note: Cell and Molecular Biology
Shabana Kouser Ali1* Ph.D
1Department of Bioinformatics, School of Biosciences and Technology, VIT University, Vellore, Tamil Nadu, India
*Corresponding author: Shabana Kouser Ali, Department of Bioinformatics, School of Biosciences and Technology, VIT University, Vellore, Tamil Nadu, India
This Journal aims at publishing dependable source of information on the discoveries and current developments related to Cell and Molecular Biology. This journal covers topics like Cell and Systems Biology, Cell Physiology, Biochemistry, Genetics/Gene Regulation, Genomics/Proteomics, Computational Biology, Microbial Pathogenesis, Immunology, Molecular Mechanisms of Disease, Cancer Biology.
The journal of cell and molecular biology of volume 1 and issue 1 published articles discussing topics like to determine morphometric features of red blood cells (RBCs) among various fish species from Turkey , proposed a teleological argument that mitochondrial and vascular sensitivity might be adapted and contribute to activation of cAMP signaling during long-term morphine exposure , summarized some of the general properties of molecular chaperones , an article with focus on the past and future aspects of vascular endothelial growth factor inhibitors in cervical cancer , and reviewed on proteasome inhibition in lymphoproliferative disorder .
Mesut Yilmaz et al. ., conducted this study to determine morphometric features of red blood cells (RBCs) among various fish species caught during trawl operations at the depth of 20-600m from Antalya Bay, Turkey. Eleven different fish species cell and nuclear sizes of RBCs were examined and variations were observed among the species. Species like S. solea, T. trachurus, M. barbatus, L. mormyrus, and H. dactylopterus RBCs maintained smooth morphology, while sickling with a prominent hemoglobin bar appeared in N. randalli, E. aeneus and M. merluccius. However, remaining manage to survive successfully at least 1 hour in controlled environment artificially created on board even with haemoglobin polymerisation caused by capture stress. Hence, this study showed that sickling shape in RBCs depends on the presence of solid cytoplasmic bar of hemoglobin that distorted cell shape. The mechanism of haemoglobin polymerisation in fishes, either the physiological mechanism or due to capture stress is a question to be solved in future studies.
Morphine has been used for centuries to alleviate pain, also its use is limited by a number of adverse effects, such as constipation, respiratory suppression, and the potential development of dependence and addiction. Human genetic study has revealed an association between microenvironment and risk of opioid tolerance and dependence. It is characterized that mitochondrial and vascular oxidant production were superior potency for proinflammatory responses. Mitochondrial biogenesis and the signaling cascades were thought to implicate in ER related subcellular communication and required for morphine mediated super activation. Thus, Hui Zhao et al. ., proposed a teleological argument that mitochondrial and vascular sensitivity might be adapted and contribute to activation of cAMP signaling during long-term morphine exposure. Moreover, it was also observed that alternative GR promoter usage was related with vascular and mitochondrial sensitivity and individual CREB activation, in which GR-1C and reflected GRalpha were involved in chronic morphine treatment. Therefore, the results unveiled a pivotal role of mitochondrial and vascular environment in the maintaining and potentiation of neuro-adaptive morphine activities.
Molecular chaperons are proteins that helps in the covalent binding or folding for the assembly or also for disassembly of other macromolecules in vivo, but they are not the components of these assembled structures when performing their normal biological actions. They also assemble essential proteins related to families that embrace steroid receptors, protein-kinases, ubiquitin-ligases, and transcription factors, among other families of key proteins. The chaperone heterocomplex related to steroid receptors is not only involved in the stabilization, preventing degradation, but it is also critical for the transport of these receptors and redistribution. In this article Gisela I Mazaira et al. ., summarized some of the general properties of molecular chaperones, in particular those belonging to a subfamily that is highly inducible by thermal shock, the heat-shock proteins, and review the most recent findings performed in the field of soluble protein trafficking, where molecular chaperones play a critical role.
This review article by Ghazaleh Shoja E Razavi et al. ., focuses on the past and future aspects of vascular endothelial growth factor inhibitors in Cervical Cancer. Vascular endothelial growth factor (VEGF)-mediated angiogenesis is known to play a significant function in the tumor development and metastasis. Therefore, VEGF-inhibitors are being actively considered as potential anti-cancer treatment. The most extensively studied tyrosine kinase inhibitors that target anti- VEGF monoclonal antibodies and receptors, promise important results in clinical trials.
Proteasomes are multi-subunit protein complexes with numerous targets for therapeutic interference. The most commonly used proteasome is 26S having one 20S proteolytic core subunit and two 19S regulatory cap subunits. Bortezomib is anti-cancer drug which is also the first therapeutic proteasome inhibitor to be used in humans. Timothy Allen et al. ., reviewed on proteasome inhibition in lymphoproliferative disorder. The development of novel proteasome inhibitor is in progress, which can block the catalytic active site of proteasome in tumors and enhance the therapeutic effectiveness and also reduce the resistance to irradiation and chemotherapies in tumors. However, a deep study is required to identify the safety and the therapeutic range of proteasome inhibitors, and their effects on immune system against cancer.
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- Yilmaz M, Guven O, Mutaf BF. Comparative Morphometry of Erythrocytes of Different Fish Species. J J Cell Mol Bio. 2015, 1(1): 1-4.
- Zhao H, Mou H, Li X, Huang HW. Mitochondria and Vascular Sensitivity during Long-term Morphine Exposure. J J Cell Mol Bio. 2015, 1(1): 1-11.
- Mazaira GI, Lagadari M, Erlejman AG, Galigniana MD. Molecular Chaperones Shape Steroid Receptor Action and Pharmacologic Strategies. J J Cell Mol Bio. 2015, 1(1): 1-7.
- Razavi GSE, Giridhar MNV, Allen T. Role of Vascular Endothelial Growth Factor Receptor Inhibitors in Refractory Cervical Cancer. J J Cell Mol Bio. 2015, 1(1): 1-8.
- Allen T, Giridhar MNV, Razavi GSE. Proteasome Inhibition in Lymphoproliferative Disorder. J J Cell Mol Bio. 2015, 1(1): 1-9.