Editor note: Experimental Cardiology and Research
Shabana Kouser Ali1* Ph.D
1Department of Bioinformatics, School of Biosciences and Technology, VIT University, Vellore, Tamil Nadu, India
*Corresponding author: Shabana Kouser Ali, Department of Bioinformatics, School of Biosciences and Technology, VIT University, Vellore, Tamil Nadu, India
Jacobs Journal of Experimental Cardiology and Research is an international peer-reviewed, open-access online journal publishing the latest findings in cardiology research. It promulgated clinical, scientific, medical articles experimental and medical research on various subjects of cardiology. From prevention to diagnosis and treatment, research in cardiology has saved millions of lives. Keeping track of globally trending research topics in cardiology can help healthcare providers make the best decisions for their patients. It can also help researchers make decisions about the direction of future projects, and provide input for institutions to develop the research strategies.
Journal of Experimental Cardiology and Research of Volume 1 Issue 1 publishes articles with discussion on analytical role of right ventricle in mitral valve surgery for ischemic mitral regurgitation (IMR) , the potential pleiotropic effects of thienopyridines , a case report of novel functional triad of severe aortic valve stenosis, right coronary artery and main stem equivalent atherosclerosis causing effort induced syncope , a review on stem cell mediated medicine for the cardiovascular disease , and study on the efficacy and safety of novel sirolimus-eluting biodegradable PLGA polymer coated stent in human coronary artery lesions .
Mitral valve regurgitation is a condition in which the heart mitral valve doesn’t close tightly and blood flow backward into the heart. In the article by Michele et al. , analytical role of right ventricle in mitral valve surgery for ischemic mitral regurgitation (IMR) is discussed. From March 2006 to march 2010 about 172 patients operated were enrolled for this study. Overall, five year cardiac survival conformed by multivariate analysis was 85% and the presence of an abnormal right ventricle is a risk factor for patients both with and without Pulmonary Hypertension. Therefore, author concludes that the right ventricle dysfunction and dilation should consider for calculating and considering the risk stratification model since both the conditions (ventricle dysfunction and dilation) are able to impair cardiac mortality unconventionally from Pulmonary Hypertension.
In the initiation and development of atherosclerotic disease platelet activation is fundamentally involved that results in the formation of triad of inflammation thrombosis and atherosclerosis. Thienopyridines are class of selective, irreversible ADP receptor inhibitors used for their anti-platelet activity and most commonly prescribed drugs for secondary prevention of cardiovascular diseases. Ashish Shah et al. , focused on the potential pleiotropic effects of thienopyridines. There are evidence reporting the beneficial effects of thienopyridines such as increasing no bioavailability, suppression of markers involved in inflammation, altering progression of atherosclerosis, beyond blockage and inhibition. However, data supporting their role in primary prevention of cardiovascular disease is lacking, trials with large samples examining overall efficacy of thienopyridines in primary prevention and long-term clinical outcomes are necessary.
Thomas et al. , presented a case report of novel functional triad of severe aortic valve stenosis, right coronary artery and main stem equivalent atherosclerosis causing effort induced syncope. It is hypothesized that these three pathologies are proposed to be functionally synergistic resulting into hypoperfusion of the myocardium on exertion. Author concluded the functional synergy between the triad is proposed as an unusual cause of exertional syncope and suggested the conventional surgical management with replacement of valve and bypass grafting is therapeutic.
Sung-Whan Kim et al. , reviewed one of the most interesting ongoing topic of research i.e. stem cell mediated medicine for the cardiovascular disease. Utilizing stem cell as medicine is an attractive source for repairing cardiovascular tissue and regenerating with its paracrine effects and miRs. Even though, stem cell therapy gives hope for near future; there are many shortcomings on current application with its physiological efficiency, safety, and delivery, along with its preclinical and clinical studies significant to examine their in vivo distribution and functional relevance. However, in terms of functional enhancement of stem cells research studies should be advanced in terms by applying genetic modification, and conditional changes. Author concludes with the specific research work on cell mechanism and communication, in particular to stem cell mediated medicine that can help restore better cardiovascular disease by understanding of their biological functions.
Qiu-Ping et al. , accord a research article scrutinizing the efficacy and safety of novel sirolimus-eluting biodegradable PLGA polymer coated stent in human coronary artery lesions. Also, list its effects on neointimal proliferation. The novel PLGA polymer coated sirolimus-eluting stent proved to be effective and safe in averting neointimal after implanting atherosclerotic human coronary arteries. This stent is potentially viable, safe and efficient clinical alternative. Yet, more multicenter trails are significant.
- Michele M. “Prognostic Role of Right Ventricle in Mitral Valve Surgery for Ischemic Mitral Regurgitation” J J Exper Cardiol Res. 2014, 1(1): 001.
- Shah A. Thienopyridines-Beyond ADP Antagonism: A Review of Pleiotropic Effects. J J Exper Cardiol Res. 2014, 1(1): 003.
- Cahill and Kardos. Severe Bicuspid Aortic Valve Stenosis, Single Right Coronary Artery and Main Stem-Equivalent Atherosclerosis: A Functional Triad Causing Effort-Induced Syncope. J J Exper Cardiol Res. 2014, 1(1): 004.
- Sung-Whan K. Stem Cell-Mediated Medicine for the Cardiovascular Disease. J J Exper Cardiol Res. 2014, 1(1): 005.
- Chen M. Efficacy and Safety of the Novel Sirolimus-Eluting, Biodegradable Polymer Coated Stent in Human Coronary Lesions. J J Exper Cardiol Res. 2014, 1(1): 006.