Sreedevi V*1 Ph.D
1 Department of Biochemistry, Institute of Genetics, Osmania University, Hyderabad, Telangana, India
*Corresponding author: Department of Biochemistry, Institute of Genetics, Osmania University, Hyderabad, Telangana, India. Email: email@example.com
Journal of Organic Chemistry is an international, peer-reviewed, open access online journal encompassing all topics within the field of organic chemistry. It aims to provide in-depth reviews on the current progress in the fields of asymmetric synthesis, organo-metallic chemistry, bioorganic chemistry, heterocyclic chemistry, natural product chemistry and analytical methods in organic chemistry. It provides a platform for rapid publication of quality research articles, reviews and brief communications contributions that concerns with analytical characterization, advanced techniques and the studies of properties for new synthesized molecules will also be highlighted.
Journal of Organic Chemistry Volume 1 Issue 1 published articles discussing Synthesis of Pyran, Pyridine, Thiophene, Pyrimidine and Thiazole Derivatives with Antitumor Activities , and Spectral and Antimicrobial Activity of Picric Acid Charge-Transfer Complex with Modified Poly (Propylene Amine) Dendrimer .
Mohareb et al. ., presented study aim is synthesis of pyridine, pyran, thiophene, thiazole, pyrimidine, chromen derivatives using 4- methyl cyanoacetanilide for anti-tumor evaluations. the work resulted in synthesis of various 2-aminopyran, 2-hydroxypyran, 2-amino pyridine, 2-hydroxypyridine, 4,5,6,7-tetrahydrobenzo[b]thiophene, N-benzal,N-acetyl, N-phenylthiourea, thiazole, pyrimidine, phenylhydrazone, benzalydine, ethoxyethine and N- phenylmethino derivatives. This obtained products were studied against cancer. In the current examination authors developed new and effective methods for synthesis of various pyran, pyridine, thiophene, pyrimidine and thiazole derivatives. This anti-tumor activity was examined against newly synthesized products against different tumor such as MCF-7, NCI-H460, SF-268. This compound showed highest inhibitory effect among tested compounds through cancer cell lines.
Ivo Grabchev et al. ., studied spectral and antimicrobial activity of picric acid charge-transfer complex with modified poly (propylene amine) dendrimer. Dendrimer are new monodisperse class of polymers with well-defined molecular structure combined with the photophysical properties of low-high molecular weight substances. The main photophysical characteristics have been investigated in organic solvents of different polarity and it was shown that [PPA8(PA)4] dendrimer emits yellow-green fluorescence. The formation of charge transfer complex of PPA8 and PA was investigated spectrophotometrically in chloroform at room temperature by fluorescence spectroscopy and it was found a complex formation with 1:4 stoichiometry. The [PPA8(PA)4] complex exhibited antibacterial and antifungal activity against various species of bacteria and yeasts. Investigation of the antimicrobial activity of such type of dendrimer complexes would expand the potential biological application of the dendrimers.
For more information: https://jacobspublishers.com/january-2018-volume-1-issue-1-organic-chemistry/
The Journal welcomes articles from all the fields related to Organic Chemistry.
- Mohareb, Ensaf S. Alwan. Synthesis of Pyran, Pyridine, Thiophene, Pyrimidine and Thiazole Derivatives with Antitumor Activities J J Organic Chem. 2016, 1(1): 001
- Desislava Staneva, Evgenia Vasileva-Tonkova, Paula Bosh, Ivo Grabchev* Spectral and Antimicrobial Activity of Picric Acid Charge-Transfer Complex With Modified Poly(Propylene Amine) Dendrimer. J J Organic Chem . 2016, 1(1): 002.