Editor Note: Spine

Editor Note

Spine

Priyanka P1* Ph.D

*Corresponding author: Priyanka P, Department of Environmental Toxicology, Institute of Genetics, Osmania University, Hyderabad, Telangana, India

The spine is consisting of 33 individual bones stacked one on top of the other. This spinal column provides the main support for your body, enabling us to stand upright, bend, and twist, also, while protecting the spinal cord from injury. Strong muscles and bones, flexible tendons and ligaments, and sensitive nerves contribute to a healthy spine. However, any of these structures are affected by strain, injury, or disease can result into pain.

This journal is to support the further development of highly innovative all spine surgeries and to provide an integrated and balanced view of diagnostic, research and treatment procedures that will improve effective collaboration among specialists worldwide. Journal of Spine Volume 1 Issue 1 publishes articles exploring Periprostetic osteolysis after 2 level cervical disc Arthroplasty featuring artificial nucleus [1], High-throughput screening of interaction partners for MAGE-H1 during retinoic acid-induced neural differentiation of P19 cells using SILAC-Immunoprecipitation quantitative proteomics approach [2], and wireless dorsal root ganglion stimulation for treatment of chronic pain: a review and update on recent advances with minimally invasive stimwave wireless technology [3].

Periprosthetic osteolysis originates from chronic inflammatory responses triggered by implant-derived particulate debris causing recruitment of cells like as macrophages, fibroblasts, lymphocytes and osteoclasts. Jacob et al. [1]., presented a rare case of peri-prostetic osteolysis in the cervical spine of a 60-year-old man undergoing replacement of a C4/5 and C5/6 M6-C cervical disc arthroplasty in Germany 2007. With this new implantation that mimics the human disc initially the patient did well but after the procedure revealed extensive periprosthetic osteolysis in the vertebral bodies of C4, C5, and C6. The patient afterward underwent removal of the artificial discs upon pathological evaluation of vertebral body bone adjacent to the implants confirmed metallic particles and extensive foreign body giant cell reaction. The current report presents a rare case of periprosthetic osteolysis in a patient status post cervical disc arthroplasty.

The melanoma antigen (MAGE) family comprises 30 genes in mouse. The MAGE family of proteins is divided into two classes (type I and type II) based on their expression pattern. Type I MAGE is completely silenced in normal tissues except male germ cells and placenta, whereas type II MAGE is expressed in both tumors and a fraction of normal tissues. The type II MAGE proteins may be divided further into two subgroups of which is MAGE-H1 and is known as Restin. MAGE-H1 is identified as one of pro-apoptotic genes that determined the response of multiple tumor cells to CD95-mediated apoptosis. MAGE-H1 may function as a tumor suppressor, which is similar to Necdin and Mage-D1. However, fundamental roles of MAGE-H1 during neurogenesis still need to be further investigated. In this study, Yong Liu et al. [2]., used Stable Isotope Labeling by Amino acids in Cell culture (SILAC) -immunoprecipitation quantitative proteomics to identify interaction partners of MAGE-H1 during retinoic acid (RA)-induced neural differentiation of P19 cells, and found that 62 proteins could specifically interact with MAGE-H1. Subsequently, they performed functional annotation of the identified proteins. The 62 proteins were given to 10 functional categories according to biological processes, and 12 functional categories according to pathways. Finally, author confirmed endogenous complex formation between MAGE-H1 and the identified proteins, such as Glutathione S-transferase P 1(GSTP1), myosin-Ib (MYO1B) or Inosine-5’-monophosphate dehydrogenase 2(IMDH2), in P19 cells treated with RA for 6 days. Those results may provide clues to further elucidate the functions of MAGE-H1 during neural differentiation. In summary, this work describes the identification of interactors of MAGE-H1 and involvement of those interactors in the biological processes and pathways during RA-induced neural differentiation of P19 cells. These findings may provide clues to further elucidate the functions of MAGE-H1 during neural differentiation.

Neuromodulation for relief of chronic back has been accepted as a treatment of choice because of its cost effectiveness while the technology has evolved to recruit new targets for stimulation and minimally invasive techniques. Dorsal root ganglion (DRG) is one such new target and wireless stimulation is an advancement in neuromodulation. A review by LT Perryman. [3]., on dorsal root ganglion stimulation (DRGS) as an alternative neuromodulation technique to conventional spinal cord stimulation (SCS) is presented. DRGS by a novel, minimally invasive wireless technology in the management of chronic back pain and leg pain following failed back surgery. DRGS provided more than 50% relief in multicenter studies by conventional apparatus with risks of CSF leak (8%) and wound infection (10%). Motor stimulation in 11% and loss of stimulation in 4% were observed. Wireless DRGS in this pilot study is safe and took an average time of 10 minutes to complete the procedure. Overall pain reduction is close to 60%. From the implantation to the explant (45 days) no adverse events were noted. Results from other ongoing studies are awaited. It is concluded that the chronic pain is challenging at all frequencies of stimulation and with the currently available targets and technologies. DRGS by a novel miniature stimulation system with wireless operational capabilities is a feasible approach to minimize the adverse events and to improve the acceptability of the available neuromodulation methods.

For more information: https://jacobspublishers.com/january-2018-volume-1-issue-1-spine/

The Journal welcomes articles from all the fields related to Spine.

Reference:

  1. Ruzevick JJ, Wagner T, Christoph PH * Periprostetic Osteolysis After 2 Level Cervical Disc Arthroplasty Featuring Artificial Nucleus. J J Spine. 2017, 1(1): 001
  2. Yong Liu*, Yujian Chen, Shide Lin, Haiping Que, Shuguang Yang, Shaojun Liu* High-Throughput Screening of Interaction Partners for MAGE-H1 during Retinoic Acid-Induced Neural Differentiation of P19 Cells Using SILAC-Immunoprecipitation Quantitative Proteomics Approach. J J Spine. 2017, 1(1): 002
  3. LT Perryman MS, MBA* Wireless Dorsal Root Ganglion Stimulation for treatment of chronic pain: A Review and update on recent advances with minimally invasive Stimwave Wireless Technology. J J Spine. 2017, 1(1): 003.

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