Editor Notes- AIDS/HIV

Editor Note

AIDS/HIV

KK Durga
Institute of Genetics, Osmania University, Begumpet, Hyderabad-500017, India.
*
Corresponding author: KK Durga, M.Sc., Ph.D, Institute of Genetics, Osmania University, Begumpet, Hyderabad-500017, India; E-mail:  durgakk08@gmail.com

This journal aims to keep scientists, clinicians, researchers, students, and general public aware of AIDS-related information with a strong focus on basic, clinical and translational science as well as on epidemiology and disease prevention. The journal of volume 1 issue 2 presented studies on the trends in the prevalence of HIV-seropositivity in pregnant women, also, explored the perspectives on HIV/AIDS awareness and study on the screening of HLA-B*5701 gene among HIV/AIDS patients among urban and rural South African adults, and highlighted opportunistic infections (OIs) and non-OIs conditions responsible for admission of PLWH at Princess Marina Hospital.

HIV Infection is still a pandemic in sub-Saharan Africa. Women and children are the most vulnerable. Early antenatal Care clinic (ANC) evaluations and screening for infections have been used as a reflection of HIV dynamics in the community to reduce the chances of pregnant women transferring infections to their children. Hannah et al. [1], studied the trends in the prevalence of HIV-seropositivity in pregnant women to get an idea of the effectiveness of preventive measures. Out of total 37464 women, 5.9% were HIV positive. There was a high incidence of late initiation of ANC, low educational attainment in the HIV positive women. On that account measures to prevent HIV transmission should be strengthened and educate school age girls.

In South Africa 6.3 million people, an estimated 12.2% of the population are living with HIV, resulting in the country with the highest HIV prevalence. Hendra van Zyl. [2]., explored lay perspectives on HIV/AIDS awareness among urban and rural South African adults, so as to make recommendations to improve HIV/AIDS prevention programs. Internalized knowledge led many participants to express concern of deteriorating moral values, negatively affecting community discourses and undergoing voluntary counselling and testing. Recommendations focus on practice, policy and research which could improve cultural acceptability of HIV/AIDS prevention programs and better understanding to encourage community discourses, reflection and ownership.

Abacavir is medication to treat HIV/AIDS and are used in combination with other antiretroviral agents as it inhibits the viral replication. It is also associated with significant risk of hypersensitivity reactions. The HLA-B*5701 gene presents peptides to immune cells. Nwagu Chinyere et al. [3]., aimed to study the screening of HLA-B*5701 gene among HIV/AIDS patients in south-eastern Nigeria. Total of 150 subjects (65 males and 85 females) and HLA typing was done by using sequence specific oligonucleotide probes PCR (SSOP-PCR). About 5.3% i.e. 4 males and 4 females were tested to be positive. However, a low but medically significant prevalence of HLA-B*5701 was documented. Author recommended the screening of HLA-B*5701 on HIV/AIDS patients to avoid the use of abacavir therapy.

John Thato Tlhakanelo et al. [4]., highlighted opportunistic infections (OIs) causing hospital admissions among people living with HIV (PLWH) in Botswana. In this account, 179 HIV+ patients record was studied and biomedical and socio-demographic data were collected. Statistical analysis was carried utilizing bivariate analysis and a logistic regression model.  Further, author concludes that the outstanding findings in this study are that OIs were major causes of admission to hospital among PLWH in Botswana.

Studies on correlation of PLWH other than OIs are need to be investigated critically to inform health policies and priorities. This work from Jose Gaby Tshikuka Mulumba et al. [5]., highlights non-OIs conditions responsible for admission of PLWH at Princess Marina Hospital (PMH), one of the two main referral hospitals for HIV patients in Botswana, and identifies correlates of the admissions to inform health policies and priorities. Data analysis and potential correlates of non-OIs admissions were investigated in two regression sub-models. From the analysis 480 individuals per 1000 admissions among HIV-infected patients were seen to be non-OIs of which 67.0 cases were of suicides. However, from this result it is evident that PLWH is solely not responsible for triggering morbidity, thus need more various approaches for prevention.

For more information: https://jacobspublishers.com/jacobs-journal-of-aids-hiv/

Further, the Journal welcomes articles from all the fields related to AIDS/HIV.

Reference

  1. Hannah E. Omunakwe*, Caroline Iyalla, Dorothy A. Okoh. Trends in the Prevalence of HIV-Seropositivity in Pregnant Women Initiating Antenatal Care in South-South, Nigeria.
  2. Hendra van Zyl*, Deborah McGill. Lay Perspectives How HIV/AIDS Prevention Programmes Influenced Selected Urban and Rural South Africans.
  3. Nwagu Chinyere, Ureme Samuel, Dick Pere Diweni, Nna Emmanuel, Adegoke Adebayo, Adias Teddy Charles. Prevalence of Human Leucocyte Antigen HLA-B*5701 among HIV-1 Infected Individuals in South Eastern Nigeria.
  4. John Thato Tlhakanelo, Jose Gaby Tshikuka Mulumba*, Mooketsi Molefi, Mgaywa Gilbert Mjungu Damas Magafu, Reginald Blessing Matchaba-Hove and Tiny Masupe. The Burden of Opportunistic-Infections and Associated Exposure Factors among HIV-Patients Admitted at a Botswana Hospital.
  5. Jose Gaby Tshikuka Mulumba*, Ph.D., John Thato Tlhakanelo, Bsc, MBChB., Mooketsi Molefi, MBChBSc., Mgaywa Gilbert Mjungu Damas Magafu, MD, MPHM, MPH, MSc, Ph.D., Reginald Blessing Matchaba-Hove, MBChB, MSc., Tiny Masupe, MBChB, MPH., MSc. Naoko Shimizu Magafu, BSc, MNS. Correlates of Hospital Admissions due to Non-Opportunistic Infections Including Attempted Suicide among HIV Patients at a Botswana Referral Hospital.

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