Gastroenterology and Hepatology
*Corresponding author:Durga K K, Department of Genetics, Osmania University, Hyderabad, Telangana, India.
Jacobs Journal of Gastroenterology and Hepatology highlights the areas of clinical gastroenterology and hepatology, including the diagnostic, endoscopic, interventional, and therapeutic advances in cancer, inflammatory diseases, functional gastrointestinal disorders, nutrition, absorption, and secretion. The journal of volume 2 issue 2 publishes articles detecting the evidence of hepatitis B and C in asymptomatic pregnant women, another article on epidemiology of alcohol abuse and hepatocellular carcinoma, and a test regarding the in vitro gas production of various dietary fibre sources involved with faecal microflora.
Hepatitis B e antigen (HBeAg) indicates viral replication and active infection is described as HBeAg-positive or HBeAg-negative according to which antigen is secreted. About 70-80% of HBeAg-positive mothers are infected with HBV when they are pregnant and have chances of infecting their non-immune newborns. Of which 90% of infants are likely to develop chronic Hepatitis B or hepatocellular carcinoma. Taofeeq Ayodeji Awogun et al. ., aimed to detect evidence of HB and C viral infections in obtained sera of asymptomatic pregnant women. However, from the study carried out it was observed that the high HB, HC and dual infection rates imply high carrier status among the asymptomatic pregnant women, thus increasing the possibility of infecting newborns. Hence, it is concluded that HB, HC and dual infection with both viruses had high prevalence rates, implying high carrier status for both viruses, among the asymptomatic pregnant women and females of reproductive age attending the two healthcare facilities in Ilesa and Ibadan, southwestern Nigeria.
Michael. ., presented an article studying epidemiology of alcohol abuse and hepatocellular carcinoma. Men generally consume more alcohol than women do and have higher death rates. Currently heavy alcohol consumption is linked with a more than 5-fold increased cumulative probability of death. Heavy alcohol consumption can result in the development of hepatocellular carcinoma. This can be said as with the consumption of more than 60 grams of alcohol per day for 10 years the risk of developing the tumor nears to 1%. The tumor usually, but not invariably, develops in the presence of cirrhosis. With the emergence of obesity and another metabolic syndrome as an increasingly significant cause of hepatocellular carcinoma (HCC), the importance of abuse of alcohol as a cause of HCC has tended to take a ‘back seat’ in the recent literature. But alcohol abuse continues to increase in many countries and remains one of the major causes of HCC in both developed and non-developed regions. In conclusion, author says alcohol abuse persists or is increasing in both men and women in many countries. It carries a poor prognosis in its own right, and has become an increasingly important cause of HCC with its grave prognosis.
Patients suffering from cystic fibrosis (CF) often suffer from an exocrine pancreatic insufficiency (PEI) and have an increased risk for distal intestinal obstruction syndrome (DIOS). To ensure a high energy density in the diet to prevent malnutrition and meteorism in these patients the dietary fibre supply is low which might exacerbate constipation and DIOS. Anne et al. ., aimed to test in vitro gas production of various dietary fibre sources involved with faecal microflora and the applicability of preventing DIOS in patients suffering from pancreatic exocrine insufficiency. In this study, four fibre sources were tested: Pure methylcellulose, two lignocellulose products and a pea fibre. The in-vitro gas production was continuously measured over 48 hours and recorded every minute using the ANKOM gas production system. From obtained results, authors concluded that the use of highly concentrated fibre sources (60 % crude fibre) might be an option to increase fibre supply in patients suffering from PEI in case of CF with no risk of bloating and with no need to markedly increase the amount of food intake. Also, suggested that as in-vitro gas production differed remarkably between fibre sources, the fibre used for dietary measures should be chosen carefully.
Further, the Journal welcomes articles from all the fields related to Gastroenterology and Hepatology.
- Taofeeq Ayodeji Awogun, Mercy Ebere Okoroji, Oluwadabira Ayodeji Taiwo, Abisola Odunayo Adegoke, Tobi Olumide Obijimi, Ayooluwa Busayo Ajetomobi, Samie Adenike Adekunle, Waidi Folorunso Sule. High Rates of Hepatitis B and C Viral Infections in Asymptomatic Pregnant Women and Females of Reproductive Age in Ilesa and Ibadan, Southwestern Nigeria. J J Gastro Hepato. 2015, 2(2): 014.
- Michael C. Kew. Alcohol Abuse and Hepatocellular Carcinoma: Epidemiology. J J Gastro Hepato. 2015, 2(2): 015.
- Anne Mößeler, Sandra Vagt, Martin Beyerbach, Josef Kamphues. In-vitro Gas Production of Different Dietary Fibre Sources Incubated with Faecal Microflora to Test Applicability of Preventing DIOS in Patients Suffering from Pancreatic Exocrine Insufficiency – Studies in Minipigs Used as A Model for Humans. J J Gastro Hepato. 2015, 2(2): 016.