Gastroenterology and Hepatology
*Corresponding author:Durga K K, Department of Genetics, Osmania University, Hyderabad, Telangana, India.
This journal covers various areas of clinical gastroenterology and hepatology, including the diagnostic, endoscopic, interventional, and therapeutic advances in cancer, inflammatory diseases, functional gastrointestinal disorders, nutrition, absorption, and secretion. The journal of volume 1 issue 2 published articles on belladonna alkaloids/phenobarbital for diminishing IBS, a case of Henoch-Schonlein purpura occurring in a female adult patient suffering from ulcerative colitis, and in one article author hypothesized cytology-based diagnoses in pancreatic cystic lesion.
A pancreatic cystic lesion is a fluid filled sac and heterogenous group ranging from non-neoplastic to malignant. Endoscopic ultrasound (EUS) are know to be safe and useful tool in term of diagnosis of cystic pancreatic lesion. EUS -guided fine needle aspiration (FNA) of pancreatic lesions is now a routine practice in many clinics. Michele et al. ., hypothesized cytology-based diagnoses may be more predictive with cyst fluid carcinoembryonic antigen (CEA). CEA levels were measured in all 44 biopsies and all cases had at least five years of clinical follow-up. It was observed good agreement between the blinded review of the cytologic preparations and the original cytologic diagnosis, which was based on all available clinical information, including cyst fluid CEA levels.
Henoch-Schonlein purpura (HSP) is a disease involving inflammation of small blood vessels by immune complex depositions, and affects the skin, joint, kidneys and gastrointestinal tract, especially in children. Here, Christoph et al. ., reported a rare case of HSP occurring in a female adult patient suffering from ulcerative colitis. The patient presented with acute abdominal pain, bloody diarrhoea, palpable purpura and had a history of UC. They described a rare manifestation of HSP in a female patient that emerged during active UC. Author discussed pathophysiological mechanisms underlying both HSP and ulcerative colitis in detail, which can stimulate the further discussion about or coincidence of both disorders.
Phenobarbital slows the activity of the brain and nervous system, whereas Belladonna alkaloids produce many effects in the body, including reduced muscle spasms in the digestive or urinary tract. The combination of belladonna alkaloids and phenobarbital is used to treat irritable bowel syndrome and ulcers in the intestine. Irritable bowel syndrome (IBS), is characterized by abdominal discomfort, bloating, and abnormal defecation without organic cause, that has 10-15% prevalence in the U.S. For this, Belladonna alkaloid/phenobarbital known as (Donnatal™), may provide an effective treatment. Ralph Turner et al. ., evaluate belladonna alkaloids/phenobarbital for diminishing IBS symptoms in patients presenting with both IBS-C and IBS-D. The treatment significantly reduced night pain in patients and result in higher global improvement. This finding suggest that belladonna alkaloids/phenobarbital is an effective addition to the treatment regimen currently offered to patients with IBS.
Further, the Journal welcomes articles from all the fields related to Gastroenterology and Hepatology.
- Terry KM. Diagnostic Accuracy of Pancreatic Cystic Lesions Evaluated by Endoscopic Ultrasound-Guided Fine Needle Aspiration Cytology. J J Gastro Hepato. 2014, 1(2): p1-5.
- Thoeringer C K. Henoch-Schönlein Purpura and Ulcerative Colitis: Comorbidity or Coincidence? J J Gastro Hepato. 2014, 1(2): p 1-4.
- Turner R R et al. Belladonna Alkaloid/Phenobarbital (Donnatal™) Effective for Treating IBS Symptoms. J J Gastro Hepato. 2014, 1(2): p1-6.