Volume 1 Issue 1

January 2018
Volume 1 Issue 1
________________________________________________________________________________________________________________________________________
Research Article
Synthesis of Pyran, Pyridine, Thiophene, Pyrimidine and Thiazole Derivatives with Antitumor ActivitiesRafat
M. Mohareb*, Ensaf S. AlwanThe aim of present study was the uses of 4- methyl cyanoacetanilide (1) in the synthesis of pyridine, pyran, thiophene, thiazole, pyrimidine, chromen derivatives together with their antitumor evaluations. The work has resulted in the synthesis of a variety of 2- aminopyran, 2- hydroxypyran, 2-amino pyridine, 2-hydroxypyridine, 4,5,6,7-tetrahydrobenzo[b]thiophene, N-benzal, N-acetyl, N-phenylthiourea, thiazole, pyrimidine, phenylhydrazone, benzalydine, ethoxyethine and N- phenylmethino derivatives. The antitumor activities of the newly synthesized product were evaluated against cancer.                                                                                            Full textDownload PDF 

________________________________________________________________________________________________________________________________________

Research Article

Spectral and Antimicrobial Activity of Picric Acid Charge-Transfer Complex With Modified Poly(Propylene Amine) Dendrimer

Desislava Staneva, Evgenia Vasileva-Tonkova, Paula Bosh, Ivo Grabchev*

The charge transfer complex of poly(propylene amine) dendrimer peripherally modified with 1,8-naphthalimide units from second generation (as donor) and picric acid (as acceptor) has been synthesized and characterized by elemental analysis, IR and 1H-NMR-spectroscopy. Its basic photophysical characteristics have been investigated in organic solvents with different polarity. The electronic absorption spectra indicated that the charge transfer complex was formed with proton migration from the acceptor to the donor followed by hydrogen bonding via N+–H• • •O−.

Full textDownload PDF