Jacobs Journal of Anatomy and Physiology

Effects of Anaerobic Exercise Training on S-Klotho in Young and Elderly

Published on: 2015-01-20


The purpose of the present study was to compare the association between s-klotho serum levels and IGF-1 levels in trained anaerobic sprinters and aerobically trained young adults. Methods Thirty healthy sportsmen were recruited as sprinters and endurance athletes: aerobically well trained young adults and well trained anaerobic sprinters (24.7±1.0, 24.2±1.0 years respectively), underwent maximal oxygen uptake test. Blood samples were drawn from a forearm vein after overnight fasting, s-Klotho levels in the serum were analyzed using an α-klotho Enzyme Linked Immunosorbent Assay ELISA kit, while, IGF-1 was measured by a chemiluminescent immunometric method. Results: Significant (p>0.05) differences were noted between the aerobic group and anaerobic sprinters with regard to s-Klotho (645±105.2 and 427±92.0 pg•mL-1 respectively), IGF-1 (70.2±10.9 and 94±21.5 nmol•L-1 respectively) and maximal oxygen uptake (60.3±2.7 and 55.1±2.7 mL•kg- •min-1 respectively). Conclusions Anaerobic exercise training is not a potent stimulus to increase plasma s-Klotho levels. Being an aerobic athlete, especially at an elite level, seems to be associated with decreased risk factors for major chronic diseases.


Lactic acid, IGF-1, aerobic training, untrained young adults, ?-Klotho