Jacobs Journal of Anatomy and Physiology

Molecular Regulation of Eye Development: Role of the PAX Gene

Published on: 2018-10-23


The development of eye has long been studied using classical embryological methods in birds, amphibians and primates. Early research has described interactions between different elements that take part in formation of the eye at the tissue level. But molecular regulation of eye development is a field that seems to invite further exploration. A number of ocular mutations and syndromes have been studied to elucidate regulatory molecules in eye development. Positional cloning of genes at mutated loci form the basis of functional and chromosomal location data in responsible molecules. Particular attention has been devoted in recent researches to the molecular biology of the PAX6(paired box) gene because of its high degree of conservation and its ability to regulate development of compound and simple eye structures in both vertebrates and invertebrates through loss and gain of function mechanisms. This paper comprehensively explores the molecular structure of PAX 6 gene, its role in eye development, its analogues and the full potential of its therapeutic and developmental applications.