Jacobs Journal of Anatomy and Physiology

Phermonal Components of Intact Male Mice Preputial Gland in Relation to Flutamide Effects

*Merza H. Homady
Department Of Animal Biology And Physiology, Kufa, Iran, Islamic Republic Of

*Corresponding Author:
Merza H. Homady
Department Of Animal Biology And Physiology, Kufa, Iran, Islamic Republic Of

Published on: 2018-10-29


The present study is designed to investigate the effect of 2mg/ml/day of flutamide on the melanocortin -5-recepter (MC5R); total lipid compounds; essential pheromone compounds and histological structure of the preputial gland of intact male mice after 42 days of treatment. Such treatment is resulted in a significant increase (P<0.01) of MC5R level as compared with the control group. Moreover the total lipid contents did not alter from that of the control, but most of the essential pheromones compounds are disappeared. The histological structure of the gland is atrophied and many acini are degenerated with a concomitant increased of necrosis regions in the stroma of the gland.



The preputial glands are exocrine modified sebaceous glands that are located subcutaneously in the front of the genitals of many rodents such as mice and rats. The gland is surrounded by a capsule of connective tissue, from which trabeculae extend to the interior to divide the parenchymatous tissues into acini, the acini are at different stages of maturation with numerous normal cytoplasmic organelles and healthy ovalshaped nuclei. The gland has a long excretory duct with a wide lumen lined by stratified squamous epithelium. The ducts empty into the preputial cavity. The preputial glands are the source of chemical signals (pheromones) that promotes reproduction and behavior of mice. In the house mouse, there are about 40 identified pheremonal compounds in preputial glands secretions, 31 were esters, 2 sesquiterpens, and 7 alcohols. Numerous studies have revealed that preputial glands and urine of male mice are main sources of pheromones. The preputial glands is androgen- dependent organ. Androgen, also called androgenic hormone or testoid, is the broad term for any natural or synthetic compound, usually a steroid hormone, that stimulates or controls the development and maintenance of male characteristics in vertebrates by binding to androgen receptors. This includes the activity of the accessory male sex organs and development of male secondary sex characteristics. The primary and most well-known androgen is testosterone which is the product of Dihydrotestosterone (DHT).