The Effect of Hydroxyethyl Starch 130/0.4 6% on Renal Function after Cardiac Surgery
Published on: 2018-05-21
Background: In critically ill patients, adverse effects of 6% hydroxyethyl starch 130/0.4 on renal function have been described. Patients undergoing cardiac surgery are also at risk for the development of acute kidney injury. The present study aimed to determine a possible relationship between the perioperative administered volume of 6% hydroxyethyl starch 130/0.4 and the incidence of postoperative acute kidney injury in cardiac surgery patients. Methods: We conducted a retrospective cohort study in which we included patients who underwent cardiac bypass- and cardiac valve surgery, or a combination of these. The main study endpoint was acute kidney injury, defined as a 1.5 times increase in serum creatinine from the preoperative value within 7 days postoperative. We compared the incidence of acute kidney injury between patients who received one unit-, two units- and more than two units 6% hydroxyethyl starch 130/0.4. Results: In total 3743 patients were included. The overall incidence of acute kidney injury was 10.6%. No significant difference was observed in the incidence and severity of AKI in relation to the number of units HES administered. Conclusion: In cardiac surgical patients, volumes up to 1500 ml of 6% hydroxyethyl starch 130/0.4 were not related to the incidence of acute kidney injury. Probably the contribution of other risk factors for AKI during cardiac surgery is of more importance. Therefore, it is reasonable to assume that administering HES up to the supposedly safe amount of 50ml/kg body weight per day to patients undergoing cardiac surgery, might not affect renal function.
6% Hydroxyethyl starch 130/0.4; Acute Kidney Injury; Anesthesia;Cardiac Surgery