Jacobs Journal of Bone Marrow and Stem Cell Research

Directed Differentiation of Late Stage islet Lineages Remains a Knowledge Gap in Pancreatic Endocrine Development

Published on: 2015-06-03


Directed differentiation of human embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) into approximately 210 types of functional cells in our body is the ultimate goal of regenerative medicine. The latter is a type of new medicine which is to replace/restore those cells lost through injury or disease with functional new cells. Type 1 and type 2 diabetes mellitus are pandemic metabolic disorders that currently affect approximately 400 million people worldwide, characterized by absolute and relative loss of insulin-secreting β cells and hence are candidate diseases for regenerative medicine.


Pancreatic, Endocrine Development, Islet Lineages, Empirical protocol