Jacobs Journal of Bone Marrow and Stem Cell Research
Emerging Concepts for Articular Cartilage Regeneration
Published on: 2018-06-06
Articular cartilage diseases still represent an unmet clinical need. After decades of basic, translational and clinical research, cartilage engineering still struggles in finding the best modalities for fabricating functional grafts that will endure the test of time. The classical Top Bottom approach in tissue engineering (TE) consisting in putting together cells biomaterials and growth factor is challenged by the emergence of novel ‘bottom top “concepts and technologies. Bioprinting and scaffold free (SF) cartilage engineering even though technically and conceptually different, take advantage of behavior of biological systems remembering of developmental stages. By mimicking the developmental niche it is sought that hierarchic organized and functionally adapted grafts for cartilage engineering could be produced. Several clinical trials using SF fabrication are already going on opening the perspective bottom top approaches could deliver clinically relevant solution for joint surface regeneration in the near future.