Jacobs Journal of Bone Marrow and Stem Cell Research

Endothelial Progenitor Cells (EPCs) – Clinical Implications

Published on: 2017-12-04

Abstract

The endothelium is responsible for the homeostasis of the cardiovascular system and other organs by producing and secreting molecular signals, activating and upgrading expression of receptors on many cell surfaces including endothelial cells themselves, a self-perpetuating condition that is accelerating with time until a specific mechanism blocks the signals. Most of the endothelial progenitor cells (EPCs) reside in niches within the bone marrow and are released only “on demand” when a certain trigger is activated – like ischemia or an increase in oxidative radicals or other inflammatory trigger is activated – recruiting them to remote areas of ischemia where they are most needed for regeneration of blood vessels. By mobilization cells from their niches the regenerative system can create new blood vessels – angiogenesis or vasculogenesis.

Keywords

Progenitor Cells, Hematopoietic stem cells, Angiogenesis, Blood Vessels