Jacobs Journal of Bone Marrow and Stem Cell Research

Treating Discogenic Pain with Mesenchymal Stem Cell Exosomes: What Is the Biologic Mechanism of Action

Published on: 2019-02-24


Over the last several years it has become increasingly understood by researchers and clinicians that the clinical efficacy of utilizing Mesenchymal Stem Cells to treat discogenic pain is not dependent on the cells differentiating into Nucleus Pulposus cells but entirely on their paracrine release of growth factors and exosomes. Living MSCs are not required to accomplish the release of GFs and exosomes into a disc. The purpose of this paper is to introduce the concept of using acellular MSC exosome products and the rationale of why acellular will replace all current cellular therapies both autogenous and allogeneic for the treatment of discogenic pain


Mesenchymal Stem Cells; Stem cells; Cell-based therapy; Bone Marrow Concentrate; Exosomes