Jacobs Journal of Cancer Science and Research

A Review Article on Clinical Trials on Hybrid Drugs and Nanohybrid Technologies in Drug Development that Combat Cancer

Published on: 2016-02-02


Cancer medically known as malignant neoplasia, is a group of diseases which involves unregulated cell growth. Malignant cells grow and divide uncontrollably, forming malignant tumors, which may spread to different parts of the body. There are over 200 different types of cancers that are known to affect human [1]. The American Cancer Society reported that total of 1,660,290 new cancer cases and 580,350 cancer deaths occurred in the U.S. in 2013. The cancer death rates decreased by 1.5% per year in women and by 1.8% per year in men. Death rates for major cancer sites (colorectal, lung, breast, and prostate) continue to decline due to recent advance in diagnosis and treatment in cancer at all stages. As per the facts provided by American cancer society inc, a decline of approximately 40% is seen in death cases for prostate cancer and 30 % for cancer related to other site like lung cancer, breast cancer and colon cancer is observed since 1991. Although gastric cancer is still an area needs more improvement. [2] As per the facts available for 1980 to 2005, only 3.6 to 4.9% decline is observed in mortality rate for both men and women, which is unaccountable [3]. Common treatments used for cancer are surgery, radiation therapy and chemotherapy. The chances of surviving the disease are affected by the location and type of the cancer and also on the extent of disease at the start of treatment [4].


Hybrid Drugs; Cancer; Nanocancer; Liposome Nanoparticles; Nano Hybrid Technology; Advance Chemotherapy; Nanotechnology