Extracellular Microenvironment Components of Glioblastoma as Possible Therapeutic Targets
Published on: 2014-04-04
Glioblastoma multiforme (GBM), is a highly invasive primary brain tumor representing more than half of all gliomas with an average patient survival time of only 12 to 15 months . Unlike tumors derived from peripheral tissues, GBM is known to rarely metastasize outside its original location in the central nervous system (CNS). This characteristic is attributed to both a limited survival time of GBM patients as well as the specific and unique composition of the extracellular matrix (ECM) in the brain supportive for migration and invasion by glioma cells into the normal brain tissue.