Acute lymphoblastic leukemia is a serious type of cancer that originates from the development and differentiation o the early version of lymphocytes in the bone marrow. With the advent of new technologies and discoveries, novel therapeutics were developed to treat these malignancies. Targeted immunotherapies are drugs that block the growth and spread of the cancer by interfering with specific molecules or pathways that are involved in carcinogenesis. It is a developing treatment alternative to chemotherapy and radiation. In this paper, we will discuss the current trends in various target therapies along with the different molecules involved in the proliferation of the disease.