Acute myeloid leukemia (AML) is cancer of the blood cells. This cancer specifically affects red blood cells, platelet forming cells and other white blood cells in the body; its incidence is very low in the United States with less than 3% of cancer diagnoses being for AML. Traditionally, this disease would be treated with chemotherapy or radiation therapy. Immunotherapy is a new way to fight this cancer. This therapy stimulates one’s own immune system to fight the malignant tumor. In this paper, we discuss the causes, epidemiology, and potential immunotherapeutic techniques to fight AML.