Breast cancer is considered as second most common cancer in women, after skin cancer. One out of every 8 woman in the United States is predisposed to develop breast cancer. It is usually caused by genetic mutations, using certain medication and few even hereditary disorders. Surgery, radiation therapy and chemotherapy are the traditional and mainstay of treatment of breast cancer. However, novel therapies such as targeted therapy have been subject to serious consideration. Targeted therapy mainly focuses on the molecular pathways responsible in process of carcinogenesis, tumor promotion and metastasis. In this paper, we discuss the causes, epidemiology, and potential targeted therapies techniques to treat breast cancer.