Preimplantation genetic diagnosis (PGD) is now an established approach for preventing genetic disorders, utilized for over 500 different genetic conditions and thousands of their causing mutations. If done according to the available guidelines, PGD for monogenic disorders is highly accurate and reliable, with close to 99% accuracy rate. A current wider application of PGD is due to its expanding use for common diseases, including inherited predisposition to cancer, the indication that has never been applied in prenatal diagnosis. The present paper describes our PGD experience for cancer, which is the world’s largest series, including 452 clinical cycles that resulted in birth of 171 healthy children, without predisposing genes for cancer. This may demonstrate the practical value of PGD for primary prevention of inherited predisposition to cancer.