Role of Small Breast Epithelial Mucin (SBEM) in Breast Cancer
Published on: 2014-11-01
SBEM as a kind of secreted protein, which expressed only in mammary gland and salivary gland, can be used to be a tumor marker in breast cancer and specific target in treatment. SBEM detection in Peripheral blood (PB) and tissue of breast cancer patients maybe helpful for early diagnosis, choice of treatment, decision of the degree of malignancy and risk prediction of recurrence. The changing of expression level can predict the curative effect of neoadjuvant chemotherapy. SBEM-mRNA had sensitivity and accuracy in bone marrow micrometastases in breast cancer and had direct correlation with TNM stage. SBEM is an independent risk predictor and may offer utility as a prognostic marker in triple-negative breast cancer patients. The detection of SBEM will have better application prospect because of its clear advantage in detecting of micrometastasis in breast cancer and clinical supervision.