Jacobs Journal of Cancer Science and Research

Sprouty Proteins and Cancer

Published on: 2014-05-19


Sprouty proteins are inducible modulators of mitogen-activated protein kinases/extracellular signal-regulated kinases (MAPK/ERK) pathway that regulate key cellular functions, including cell vitality, differentiation and motility. Owing to their critical regulatory functions, Sprouty proteins are well documented to participate in developmental and adult physiological processes and, consistently, to be implicated in the regulation of pathological conditions, including cancer. Since discovery in Drosophila in 1998.