Jacobs Journal of Cancer Science and Research

Tumor relapse, history, implication and future direction

Published on: 2020-03-14


Considering the extent and prevalence of the Tumor relapse, it requires the urgent attention for identifying factors involved in the relapse process and thus affecting the life span of the patients. Sensitization (SS) is a process defined on the basis of converting the Drug-Resistant Tumor Cells (DRTC) to the Drug Responsive State (DRS). The present article tries to specify and re-define the existing literature regarding the sensitization process along with its correlation to the adjuvant treatment- First correlating the sensitization adjuvant/process with approaches other than the radiotherapy/ chemotherapy which should be investigated in details in the future. The DRTC are defined on the basis of cell cycle dynamics of G0/quiescent cells state, understanding the cell biology of G0-G1 transition could become the basis of new approaches for making the cells in the DRS- In this regard noble point proposed in this article is investigating the factors involved in forcing the static cells -G0/quiescent cells- DRTC to G1 phase (drug-sensitive) - new way of looking at the sensitization process. One way to go about it is to compare with yeast genomics, like in yeast- a new hypothesis predicting different states of G0 is being proposed in the mammalian system which should be studied in details and also factors involved in the G0- G1 transition in the upstream and downstream of the genetic pathway. The third approach which should be the centre of the future research is comprehensive -coupling and un-coupling the process of SS and Anti-Tumor Therapy (ATT). Coupling approach is where agents for SS and ATT is one step process while uncoupling agents are different agents used for the former as well as for the later in two step process. This is very important as understanding this process would increase the efficacy, specificity, efficiency as well as eliminating the side effects of the sensitization process and anti-cancer therapy and ultimately affecting the life span of the tumor patients. Keywords: Anti-Tumor Therapy; Quiescence; Cell Cycle dynamics; Coupling drug agents


Keywords: Anti-Tumor Therapy; Quiescence; Cell Cycle dynamics; Coupling drug agents