Jacobs Journal of Cancer Science and Research

Novel Targets and Breast Cancer Treatment

*Timothy Allen
Department Of Oncology, Enter For Excellence In Research And Development, United States

*Corresponding Author:
Timothy Allen
Department Of Oncology, Enter For Excellence In Research And Development, United States

Published on: 2017-06-23


Breast cancer is considered as second most common cancer in women, after skin cancer. One out of every 8 woman in the United States is predisposed to develop breast cancer. It is usually caused by genetic mutations, using certain medication and few even hereditary disorders. Surgery, radiation therapy and chemotherapy are the traditional and mainstay of treatment of breast cancer. However, novel therapies such as targeted therapy have been subject to serious consideration. Targeted therapy mainly focuses on the molecular pathways responsible in process of carcinogenesis, tumor promotion and metastasis. In this paper, we discuss the causes, epidemiology, and potential targeted therapies techniques to treat breast cancer.


Breast Cancer; Immunotherapy; Estrogen; Monoclonal Antibodies; T-Cell Therapy; Vaccines; Checkpoint Inhibitors


Breast cancer is one of the leading causes of death worldwide. National Cancer Institute estimated that there would be 232,670 new cases of breast cancer in females and 2,360 new cases in males in 2014. It is also estimated that there would be 40,000 cases of deaths in females and 430 cases of deaths in males in the United States in the same year. As per the statistical analysis, in the United States of America (USA), breast cancer is the second most common leading cause of death in women and around 1 in every 8 women will develop invasive breast cancer in their lifetime. The annual age-standardized incidence rates in various countries are as follows: North America, 90; Central America, 42; Western Europe, 78; Northern Europe, 73; Southern Europe, 56; South and Eastern Europe, 49; East Asia, 18; North Africa and Western Asia, 28; South-East Asia, 26; South Central Asia, 22; Oceania, 74; and sub-Saharan Africa, 22 per 100,000 females. The USA has higher incidences as compared to rest of the world.