Jacobs Journal of Cancer Science and Research

Preimplantation Genetic Diagnosis for Cancer

Anver Kuliev
Department Of Genetics, Reproductive Genetic Innovations, United States

Published on: 2017-05-02


Preimplantation genetic diagnosis (PGD) is now an established approach for preventing genetic disorders, utilized for over 500 different genetic conditions and thousands of their causing mutations. If done according to the available guidelines, PGD for monogenic disorders is highly accurate and reliable, with close to 99% accuracy rate. A current wider application of PGD is due to its expanding use for common diseases, including inherited predisposition to cancer, the indication that has never been applied in prenatal diagnosis. The present paper describes our PGD experience for cancer, which is the world’s largest series, including 452 clinical cycles that resulted in birth of 171 healthy children, without predisposing genes for cancer. This may demonstrate the practical value of PGD for primary prevention of inherited predisposition to cancer.




Preimplantation genetic diagnosis (PGD) is presently incorporated into clinical practices as a powerful tool in preventing inherited disorders, which are still not responding to any available treatment. Increasing number of PGD procedures is now being performed, allowing at risk couples to avoid the birth of children with genetic disorders, with the principle objective of achieving the birth of an unaffected babies, obviating a potential risk of pregnancy termination following prenatal diagnosis.