Jacobs Journal of Cancer Science and Research

Role of Immunotherapy for H. pylori in Gastric Cancer

*Timothy Allen
Department Of Oncology, Enter For Excellence In Research And Development, United States

*Corresponding Author:
Timothy Allen
Department Of Oncology, Enter For Excellence In Research And Development, United States

Published on: 2016-07-04


Gastric cancer is a widely well-known challenging health problem in the world, which has been deemed associated with Helicobacter pylori (H. pylori). H. pylori avoid the endogenous immune reactions. . An effective production of antibody against H. pylori is critical. There are known conventional as well as experimental treatments associated with against H. pylori. Immune therapy may be considered a cornerstone of treatments. Immunization against H. pylori may be deemed as safe and effective among many populations. H. pylori colonize the gastric mucosa of more than half of the world. Most of the aggravation associated with its infection is deemed as innocuous and/or clinically asymptomatic to treat. However, it may lead to perpetual gastritis, peptic ulcer, gastric mucosa-related lymphoid tissue lymphoma, and gastric cancer. The actual role of immune system for gastric cancer is discussed. Lately, T regulatory cells (T reg) have been inferred to be a vital part in H. pylori-related advancement. Additionally, T reg-actuated tolerance has been suggested as a plausible tool that presumes less serious infection. A number of clinical trials have been shown the mechanism of immune response against H. pylori in line with the induction in gastric cancer.


Helicobacter pylori, Vaccines; T Regulatory Cells; Gastric Cancer; Lymphoid Tissue; Lymphoma; Git


patients with cancer. H. pylori is a gastric pathogen which colonizes of approx. half of the world’s GI track. An infection with H. pylori causes chronic inflammation and considerably increases the risk associated with developing gastric cancer, gastric ulcer and duodenal ulcer condition. Infection with H. Pylori is considered a major risk associated with gastric cancer related deaths worldwide. H. pylori are often a spiral- shaped bacterium which raises from the mucus level that coat inside of the human stomach. H. pylori are colonized within the gastric Mucosa; therefore, it is uniquely adapted to the acidic environment. The production associated with ammonia all around H. pylori neutralizes the level of acidity of the stomach, turning it into additionally an agreeable environment for bacterium. Also, the helical model of H. pylori permits it to reside into mucus layer; which is less acidic as opposed to inside of space, or lumen, of the stomach. Additionally, H.pylori may also attach to the tissue which is gathering the interior surface of the stomach. The immune response of the body associated with the inner wall of the stomach is limited. Therefore, a proper response against H. pylori is effectively provided. Furthermore, H. pylori adapts to the local immune reactions, thus, it is rendered to be immune during the potential eradication process. There are many factors leading to gastric carcinoma.