Jacobs Journal of Cancer Science and Research

Second Primary Lung Cancer: A Current Problem in Long-Survivor Cancer Patients

*Felice Mucilli
Department Of Surgery, University “G. D’Annunzio “-Chieti, Italy

*Corresponding Author:
Felice Mucilli
Department Of Surgery, University “G. D’Annunzio “-Chieti, Italy

Published on: 2017-07-22


between 0.8 and 14.5% of cases. Synchronous or metachronous SPM present, however, diagnostic and therapeutic challenges. The authors report their experience in the treatment of second primary lung tumors. Methods: A retrospective study from 2008 to 2014 was conducted in patients with synchronous or metachronous second primary lung cancer. Results: 30 patients (69.8%) underwent to pulmonary lobectomy, 4 (9,3%) to segmentectomy and 6 (14.0%) to wedge resections (Table n.1). Lung-sparing resections were referred to patients with unsuitable respiratory volumes for anatomical ones. The presence in the medical history of an intra- or extrathoracic primary cancer does not significantly influence survival, while the second primary malignancy’s stage is crucial. Conclusions: Lobectomy with hilar-mediastinal lymph node dissection should be offered to all suitable patient.


Second Primary Lung Cancer; Martini and Melamed’s Criteria; Lobectomy; Overall Survival


Lung cancer is the leading cause of cancer-related death. Non small cell lung cancer (NSCLC) and Small cell lung cancer (SCLC) are the major histotypes, with the previous representing about 85% of cases. The lung may be the site of synchronous or metachronous second primary malignancies (SPM) with an incidence between 0.8 and 14.5% of cases. However, synchronous or metachronous SPMs present diagnostic and therapeutic challenges. In fact, occasionally, it is difficult to differentiate a SPM from a local recurrence or distant metastasis. Martini and Melamed’s and Antakli’s diagnostic criteria are universally accepted.