Jacobs Journal of Cancer Science and Research

Therapeutic Approach to Chordomas

*Timothy Allen
Department Of Oncology, Enter For Excellence In Research And Development, United States

*Corresponding Author:
Timothy Allen
Department Of Oncology, Enter For Excellence In Research And Development, United States
Email:Timothy.Allen@gapsos.com

Published on: 2017-05-02

Abstract

Chordomas are neoplasms that come from the notochord’s cellular remnants. Immunotherapy is a cancer treatment alternative to chemotherapy and radiation therapy. Its goal is to use a patient’s own immune system to fight the tumor. The immune system can be stimulated by exposing synthetic immune molecules into a subject’s system. In this paper, we discuss the potential causes of chordomas, the pathophysiology of the disease, and potential ways to cure the disease using different immunotherapy techniques.

Keywords

Bone Cancer; Immunotherapy; Chondrosarcoma; Osteosarcoma; Ewing Tumors; Chordomas

Introduction

Chordoma is a rare subtype of sarcoma among adult population. Available studies from the United States indicated that 400 microscopically confirmed cases of chordoma have been reported from the Surveillance, Epidemiology, and End Results (SEER) program of the National Cancer Institute, between 1973-1995. The age-adjusted chordoma incidence rate (IR) of 0.08 per 100,000 was age-dependent and more common in males (IR 0.10) than females (IR 0.06). It was rare among patients aged <40 years and blacks. Anatomically 32% of cases were cranial, 32.8% spinal and 29.2% sacral within the axial skeleton.