Jacobs Journal of Clinical Case Reports

Multifocal Deposits of Amyloidoma in the Upper Airway Accompanied by deposits in the Cervical Nodes with Recurrences

Published on: 2016-06-20


A 55-year-old man was referred to us for investigation of his dysphagia. Endoscopic examination revealed a smooth, firm, pink-yellowish, giant swelling of the epiglottis, with small nodules in the left nasal cavity, nasopharynx, and uvula. A right cervical node was slightly prominent on palpation. CT scan revealed a well-defined, homogeneous mass containing calcification spots and no enhancement on contrast-enhanced scans. Based on histologic examination, the definitive diagnosis was amyloid light chain amyloidosis. Endoscopic surgery and cervical excision of amyloidoma was performed. However, two recurrences of amyloidoma occurred after the surgeries during a period of 18 years. The patient showed no evidence of systemic amyloidosis. Multiple deposits are occasionally seen in localized amyloidoma in the upper airway, but their presence along with deposits in the lymph nodes, especially in the neck, is rare. This is the first report of recurrent amyloidoma with multifocal deposits in the upper airway and cervical lymph nodes.


Amyloidoma; Epiglottis; Upper Airway; Cervical Node; Recurrence