Jacobs Journal of Clinical Case Reports

Acute Eosinophilic Pneumonia in a Patient with Inflammatory Bowel Disease

*Jacqueline N
Department Of Medicine, Stanford University School Of Medicine, United States

*Corresponding Author:
Jacqueline N
Department Of Medicine, Stanford University School Of Medicine, United States

Published on: 2014-02-01


Acute eosinophilic pneumonia (AEP) is an uncommon respiratory disease characterized by increased eosinophilis in bronchoalveolar lavage fluid. It may be triggered by a drug, infection, or dust. The etiology may also be idiopathic, in which case the patient is usually a young, previously healthy smoker. We report a case of AEP in an elderly non-smoking patient with ulcerative colitis, treated with a total colectomy one decade prior to presentation. Though cases of AEP have been reported in association with anti-metabolite therapy for inflammatory bowel disease, our patient was not taking any such medications. He also did not have exposure to any other known triggers of AEP, and did not fit the usual clinical picture of idiopathic AEP. Therefore, we suspect that this case of AEP was a complication of the patient’s inflammatory bowel disease itself.


Acute Eosinophilic Pneumonia; Inflammatory Bowel Disease; Ulcerative Colitis; Crohn’s Disease


Pulmonary manifestations of inflammatory bowel disease (IBD) have been recognized as a rare complication since initially described in 1976, but are varied in presentation and pathology, making the diagnosis difficult. Acute eosinophilic pneumonia has been described a subtype of IBD lung disease, but previous case reports are limited to IBD drug therapy-induced eosinophilic pneumonia. Here we report a case of acute eosinophilic pneumonia in a patient with ulcerative colitis, independent of drug therapy, followed by a review of the literature on IBD-associated lung disease.