Multifocal Deposits of Amyloidoma in the Upper Airway Accompanied by deposits in the Cervical Nodes with Recurrences
* Suzuki M Department Of Otolaryngology, Teikyo University Chiba Medical Center, Japan
*Corresponding Author: Suzuki M
Department Of Otolaryngology, Teikyo University Chiba Medical Center, Japan Email:email@example.com
Published on: 2016-06-20
A 55-year-old man was referred to us for investigation of his dysphagia. Endoscopic examination revealed a smooth, firm, pink-yellowish, giant swelling of the epiglottis, with small nodules in the left nasal cavity, nasopharynx, and uvula. A right cervical node was slightly prominent on palpation. CT scan revealed a well-defined, homogeneous mass containing calcification spots and no enhancement on contrast-enhanced scans. Based on histologic examination, the definitive diagnosis was amyloid light chain amyloidosis. Endoscopic surgery and cervical excision of amyloidoma was performed. However, two recurrences of amyloidoma occurred after the surgeries during a period of 18 years. The patient showed no evidence of systemic amyloidosis. Multiple deposits are occasionally seen in localized amyloidoma in the upper airway, but their presence along with deposits in the lymph nodes, especially in the neck, is rare. This is the first report of recurrent amyloidoma with multifocal deposits in the upper airway and cervical lymph nodes.
Amyloidosis is a rare disease that is characterized morphologically by deposition of amyloid in different organs and results in a wide range of clinical manifestations. The localized form of amyloidosis without evidence of a systemic immune abnormality or chronic disease is categorized as amyloidoma. Typically, only one anatomic site, for example, the lung, larynx, skin, or bladder, is affected, and multiple deposits are rare [1,2]. Furthermore, their presence along with deposits in the lymph nodes, especially those in the neck, is particularly rare . We encountered a case of giant amyloidoma of the epiglottis with multifocal deposits in the upper airway and cervical nodes showing recurrences.